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Bone Regeneration Using N-Methyl-2-pyrrolidone as an Enhancer for Recombinant Human Bone Morphogenetic Protein-2 in a Rabbit Sinus Augmentation Model
Joint Authors
Thoma, Daniel Stefan
Yoon, So-Ra
Jung, Ui-Won
Lim, Hyun-Chang
Cha, Jae-Kook
Lee, Jung-Seok
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to determine whether N-methyl-2-pyrrolidone (NMP) can decrease the dose of recombinant human bone morphogenetic protein-2 (rhBMP-2) in sinus augmentation of rabbits.
In each of 15 rabbits, 2 sinuses were randomly grafted using 1 of 3 treatment modalities: (i) biphasic calcium phosphate (BCP; control), (ii) rhBMP-2-coated BCP (BMP), or (iii) rhBMP-2-coated BCP soaked in NMP solution (BMP/NMP).
The rabbits were sacrificed 2 weeks postoperatively.
Histologic and histomorphometric analyses were performed.
Bone formation in all groups was predominantly located close to the access window and the lateral walls.
Newly formed bone within the total augmented area (NBTA) was greatest in BMP/NMP (1.94±0.69 mm2), followed by BMP (1.50±0.72 mm2) and BCP (1.28±0.52 mm2) (P>0.05).
In the center of the augmentation (NBROI_C) and the area close to the sinus membrane (NBROI_M), BMP/NMP produced the largest area of NB (NBROI_C: 0.10±0.11 mm2; NBROI_M: 0.17±0.08 mm2); the corresponding NB values for BCP were 0.05±0.05 mm2 and 0.08±0.09 mm2, respectively (P>0.05 for all comparisons).
The effect of NMP on bone regeneration was inconsistent between the specimens.
Adding NMP as an adjunct to rhBMP-2-coated BCP produced inconsistent effects on bone regeneration, resulting in no significant benefit compared to controls.
American Psychological Association (APA)
Lim, Hyun-Chang& Thoma, Daniel Stefan& Yoon, So-Ra& Cha, Jae-Kook& Lee, Jung-Seok& Jung, Ui-Won. 2017. Bone Regeneration Using N-Methyl-2-pyrrolidone as an Enhancer for Recombinant Human Bone Morphogenetic Protein-2 in a Rabbit Sinus Augmentation Model. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136802
Modern Language Association (MLA)
Lim, Hyun-Chang…[et al.]. Bone Regeneration Using N-Methyl-2-pyrrolidone as an Enhancer for Recombinant Human Bone Morphogenetic Protein-2 in a Rabbit Sinus Augmentation Model. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1136802
American Medical Association (AMA)
Lim, Hyun-Chang& Thoma, Daniel Stefan& Yoon, So-Ra& Cha, Jae-Kook& Lee, Jung-Seok& Jung, Ui-Won. Bone Regeneration Using N-Methyl-2-pyrrolidone as an Enhancer for Recombinant Human Bone Morphogenetic Protein-2 in a Rabbit Sinus Augmentation Model. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136802