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Three-Dimensional-Printed Poly-L-Lactic Acid Scaffolds with Different Pore Sizes Influence Periosteal Distraction Osteogenesis of a Rabbit Skull
Joint Authors
Zhao, Danyang
Wang, Yu
Han, Dong
Li, Qingfeng
Jiang, Wenbo
Wang, Chuandong
Zhang, Xiaoling
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The repair of bone defects is a big challenge in reconstructive surgery.
Periosteal distraction osteogenesis (PDO), as a promising technique used for bone regeneration, forms a space between the periosteum and bone cortex to regenerate the new bone merely by distracting the periosteum.
In order to investigate the influence of distractor framework on the PDO, we utilized three-dimensional (3D) printing technology to fabricate three kinds of poly-L-lactic acid (PLLA) scaffolds with different pore sizes in this study.
The in vitro experiments showed that the customized PLLA scaffolds had different-sized microchannels with low toxicity, good biocompatibility, and enough mechanical strength.
Then, we built up an in vivo bioreactor under the skull periosteum of New Zealand white rabbits.
The distractors with different pore sizes all could satisfy the demand of periosteal distraction in the animal experiments.
After 8 weeks of consolidation period, the quality and quantity of the newly formed bone were improved with the increasing pore sizes of the distractors.
Moreover, the newly formed bone also displayed an increasing degree of vascularization.
In conclusion, 3D printing technology could promote the innovation of PDO devices and fabricate optimized scaffolds with appropriate pore sizes, shapes, and structures.
It would help us regenerate more functional tissue-engineered bone and provide new ideas for further clinical application of the PDO technique.
American Psychological Association (APA)
Zhao, Danyang& Jiang, Wenbo& Wang, Yu& Wang, Chuandong& Zhang, Xiaoling& Li, Qingfeng…[et al.]. 2020. Three-Dimensional-Printed Poly-L-Lactic Acid Scaffolds with Different Pore Sizes Influence Periosteal Distraction Osteogenesis of a Rabbit Skull. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1136811
Modern Language Association (MLA)
Zhao, Danyang…[et al.]. Three-Dimensional-Printed Poly-L-Lactic Acid Scaffolds with Different Pore Sizes Influence Periosteal Distraction Osteogenesis of a Rabbit Skull. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1136811
American Medical Association (AMA)
Zhao, Danyang& Jiang, Wenbo& Wang, Yu& Wang, Chuandong& Zhang, Xiaoling& Li, Qingfeng…[et al.]. Three-Dimensional-Printed Poly-L-Lactic Acid Scaffolds with Different Pore Sizes Influence Periosteal Distraction Osteogenesis of a Rabbit Skull. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1136811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136811