Association of RASSF1A, DCR2, and CASP8 Methylation with Survival in Neuroblastoma: A Pooled Analysis Using Reconstructed Individual Patient Data
Joint Authors
Hassan, Waleed M.
Bakry, Mohamed S.
Siepmann, Timo
Illigens, Ben
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Neuroblastoma (NB) is a heterogeneous tumor affecting children.
It shows a wide spectrum of clinical outcomes; therefore, development of risk stratification is critical to provide optimum treatment.
Since epigenetic alterations such as DNA methylation have emerged as an important feature of both development and progression in NB, in this study, we aimed to quantify the effect of methylation of three distinct genes (RASSF1A, DCR2, and CASP8) on overall survival in NB patients.
We performed a systematic review using PubMed, Embase, and Cochrane libraries.
Individual patient data was retrieved from extracted Kaplan–Meier curves.
Data from studies was then merged, and analysis was done on the full data set.
Seven studies met the inclusion criteria.
Methylation of the three genes had worse overall survival than the unmethylated arms.
Five-year survival for the methylated arm of RASSF1A, DCR2, and CASP8 was 63.19% (95% CI 56.55-70.60), 57.78% (95% CI 47.63-70.08), and 56.39% (95% CI 49.53-64.19), respectively, while for the unmethylated arm, it was 93.10% (95% CI 87.40–99.1), 84.84% (95% CI 80.04-89.92), and 83.68% (95% CI 80.28-87.22), respectively.
In conclusion, our results indicate that in NB patients, RASSF1A, DCR2, and CASP8 methylation is associated with poor prognosis.
Large prospective studies will be necessary to confirm definitive correlation between methylation of these genes and survival taking into account all other known risk factors.
(PROSPERO registration number CRD42017082264).
American Psychological Association (APA)
Hassan, Waleed M.& Bakry, Mohamed S.& Siepmann, Timo& Illigens, Ben. 2020. Association of RASSF1A, DCR2, and CASP8 Methylation with Survival in Neuroblastoma: A Pooled Analysis Using Reconstructed Individual Patient Data. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1136816
Modern Language Association (MLA)
Hassan, Waleed M.…[et al.]. Association of RASSF1A, DCR2, and CASP8 Methylation with Survival in Neuroblastoma: A Pooled Analysis Using Reconstructed Individual Patient Data. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1136816
American Medical Association (AMA)
Hassan, Waleed M.& Bakry, Mohamed S.& Siepmann, Timo& Illigens, Ben. Association of RASSF1A, DCR2, and CASP8 Methylation with Survival in Neuroblastoma: A Pooled Analysis Using Reconstructed Individual Patient Data. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1136816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136816