Prolonged Serum Alanine Aminotransferase Elevation Associated with Isotretinoin Administration
Joint Authors
Nazarian, Roya S.
Zheng, Elizabeth
Halverstam, Caroline
Cohen, Steven R.
Wolkoff, Allan W.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-17
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Isotretinoin is a highly effective oral retinoid derivative for severe forms of acne.
Despite its high margin of safety, isotretinoin carries a risk of teratogenicity and mild to massive elevations of serum cholesterol and triglyceride levels, as well as infrequent transaminitis.
Liver dysfunction induced by isotretinoin is rare but it poses a management dilemma.
We describe a 16-year-old male in whom alanine aminotransferase (ALT) rose from a baseline of 13 to 288 U/L after 20 weeks of treatment with 1.0-1.4 mg/kg of oral isotretinoin daily.
Though the patient remained asymptomatic, ALT levels did not return to normal limits for approximately 8 months after discontinuation of therapy, an observation that has not been documented in the literature.
When oral isotretinoin was readministered for intractable facial acne 3 years later, liver enzymes remained normal throughout the course of therapy.
Although the pathogenesis and prognosis of retinoid-induced hepatotoxicity are unknown, this case illustrates that isotretinoin may be safely readministered after normalization of liver function tests.
American Psychological Association (APA)
Nazarian, Roya S.& Zheng, Elizabeth& Halverstam, Caroline& Cohen, Steven R.& Wolkoff, Allan W.. 2019. Prolonged Serum Alanine Aminotransferase Elevation Associated with Isotretinoin Administration. Case Reports in Hepatology،Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1136841
Modern Language Association (MLA)
Nazarian, Roya S.…[et al.]. Prolonged Serum Alanine Aminotransferase Elevation Associated with Isotretinoin Administration. Case Reports in Hepatology No. 2019 (2019), pp.1-3.
https://search.emarefa.net/detail/BIM-1136841
American Medical Association (AMA)
Nazarian, Roya S.& Zheng, Elizabeth& Halverstam, Caroline& Cohen, Steven R.& Wolkoff, Allan W.. Prolonged Serum Alanine Aminotransferase Elevation Associated with Isotretinoin Administration. Case Reports in Hepatology. 2019. Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1136841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136841