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Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers
Joint Authors
Tan, Zhi-Rong
Chen, Yao
Tang, Yong-Jun
Hu, Kai
Huang, Wei-Hua
Liu, Zhi
Zhou, Hong-Hao
Yuan, Chun-Su
Ou-Yang, Dong-Sheng
Wang, Chong-Zhi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Sulindac is a nonsteroidal anti-inflammatory drug, which is clinically used for the ailments of various inflammations.
This study investigated the allele frequencies of FMO3 E158K and E308G and evaluated the influences of these two genetic polymorphisms on the pharmacokinetics of sulindac and its metabolites in Chinese healthy male volunteers.
Eight FMO3 wild-type (FMO3 HHDD) subjects and seven FMO3 homozygotes E158K and E308G mutant (FMO3 hhdd) subjects were recruited from 247 healthy male volunteers genotyped by PCR-RFLP method.
The plasma concentrations of sulindac, sulindac sulfide, and sulindac sulfone were determined by UPLC, while the pharmacokinetic parameters of the two different FMO3 genotypes were compared with each other.
The frequencies of FMO3 E158K and E308G were 20.3% and 20.1%, respectively, which were in line with Hardy-Weinberg equilibrium (D′ = 0.977, r2 = 0.944).
The mean values of Cmax, AUC0–24, and AUC0–∞ of sulindac were significantly higher in FMO3 hhdd group than those of FMO3 HHDD group (P<0.05), while the pharmacokinetic parameters except Tmax of sulindac sulfide and sulindac sulfone showed no statistical difference between the two groups.
The two FMO3 mutants were in close linkage disequilibrium and might play an important role in the pharmacokinetics of sulindac in Chinese healthy male volunteers.
American Psychological Association (APA)
Tang, Yong-Jun& Hu, Kai& Huang, Wei-Hua& Wang, Chong-Zhi& Liu, Zhi& Chen, Yao…[et al.]. 2017. Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1136844
Modern Language Association (MLA)
Tang, Yong-Jun…[et al.]. Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1136844
American Medical Association (AMA)
Tang, Yong-Jun& Hu, Kai& Huang, Wei-Hua& Wang, Chong-Zhi& Liu, Zhi& Chen, Yao…[et al.]. Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1136844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136844