Efficacy and Safety of Cerebrolysin for Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Zhang, Danfeng
Wang, Junyu
Dong, Yan
Hou, Lijun
Chen, Jigang
Li, Ya
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cerebrolysin was reported to be effective in the neurological improvement of patients with acute ischemic stroke (AIS) in experimental models, while data from clinical trials were inconsistent.
We performed a meta-analysis to explore the efficacy and safety of cerebrolysin for AIS.
PubMed, EMBASE, and Cochrane Library were searched for randomized controlled trials, which intervened within 72 hours after the stroke onset.
We investigated the efficacy and safety outcomes, respectively.
Risk ratios and mean differences were pooled with fixed-effects model or random-effects model.
Seven studies were identified, involving 1779 patients with AIS.
The summary results failed to demonstrate significant superiority of cerebrolysin in the assessment of efficacy outcomes of mRS and BI.
Similarly, administration of cerebrolysin had neutral effects on safety outcomes compared with placebo, including mortality and SAE.
However, the number of included studies was small, especially in the analysis of efficacy outcomes, which might cause publication bias and inaccurate between-studies variance in the meta-analysis.
Conclusively, although it seemed to be safe, routine use of cerebrolysin to improve the long-term rehabilitation after stroke could not be supported by available evidence.
American Psychological Association (APA)
Zhang, Danfeng& Dong, Yan& Li, Ya& Chen, Jigang& Wang, Junyu& Hou, Lijun. 2017. Efficacy and Safety of Cerebrolysin for Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136846
Modern Language Association (MLA)
Zhang, Danfeng…[et al.]. Efficacy and Safety of Cerebrolysin for Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1136846
American Medical Association (AMA)
Zhang, Danfeng& Dong, Yan& Li, Ya& Chen, Jigang& Wang, Junyu& Hou, Lijun. Efficacy and Safety of Cerebrolysin for Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136846