The Survival Advantage of Females at Premenopausal Age Is Race Dependent in Colorectal Cancer
Joint Authors
Sheng, Hui
Wei, Xiaoli
Chen, Qunxi
Huang, Kewei
Han, Runkun
Liu, Yijun
Liu, Wen
Mao, Minjie
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
A female prognostic advantage in younger individuals has been demonstrated in various cancers.
Several large-scale analyses based on different racial backgrounds have reported inconsistent results in colorectal cancer.
The aim of the present study was to evaluate the prognostic value of sex and age in patients with colorectal cancer of different ethnic groups.
Methods.
We identified 71,812 eligible patients from the Surveillance, Epidemiology and End Results database.
According to age at diagnosis, the patients were categorized into premenopausal age (≤45 yrs), menopausal age (46–54 yrs), and postmenopausal age (≥55 yrs) subgroups for further analysis.
Results.
Multivariate analysis identified the female survival advantage to be significant in the premenopausal age subgroup (P=0.002, HR (95% CI): 0.73 (0.60–0.89)), diminished in the menopausal age subgroup (P=0.09), and absent in the postmenopausal age subgroup (P=0.96).
Furthermore, the female survival advantage at premenopausal age was significant only in white patients (P=0.001, HR (95% CI): 0.68 (0.54–0.87)) and not in either American Indian/Alaska Native or Asian or Pacific Islander patients.
There was a trend of better survival of females in black patients (P=0.07).
Conclusions.
Sex was a major prognostic factor in colorectal cancer patients, especially premenopausal women, and the difference was also associated with race.
American Psychological Association (APA)
Sheng, Hui& Wei, Xiaoli& Chen, Qunxi& Huang, Kewei& Han, Runkun& Liu, Yijun…[et al.]. 2020. The Survival Advantage of Females at Premenopausal Age Is Race Dependent in Colorectal Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136865
Modern Language Association (MLA)
Sheng, Hui…[et al.]. The Survival Advantage of Females at Premenopausal Age Is Race Dependent in Colorectal Cancer. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136865
American Medical Association (AMA)
Sheng, Hui& Wei, Xiaoli& Chen, Qunxi& Huang, Kewei& Han, Runkun& Liu, Yijun…[et al.]. The Survival Advantage of Females at Premenopausal Age Is Race Dependent in Colorectal Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136865