Castleman Disease in a Patient with Common Variable Immunodeficiency
Joint Authors
Ieni, A.
Ricciardi, Luisa
Furci, Fabiana
Macrì, Antonio
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Common variable immunodeficiency (CVID) is a primary immunodeficiency due to a disorder of the adaptive immune system which causes hypogammaglobulinemia and therefore an increased susceptibility to infection; noninfectious, inflammatory conditions including systemic autoimmunity and lymphoproliferative complications are also commonly associated with CVID.
Castleman disease (CD) is a systemic disease clinically characterized by diffuse lymphadenopathy, splenomegaly, anemia, and systemic inflammatory symptoms.
This makes CD a great mimicker of more common benign and malignant masses in the neck, chest, abdomen, and pelvis.
A novel case of primary immunodeficiency (CVID) in a middle-aged woman, who developed multicentric CD (MDC) with splenomegaly, is described.
The authors suggest that the onset of MCD and of the correlated splenomegaly was due to incorrect management of the hypogammaglobulinemia as immunoglobulin G (IgG) levels were not kept within normal ranges.
Correct management of the hypogammaglobulinemia allowed splenectomy to be performed without any infectious surgical complications.
MCD is reported for the first time in association with an adult case of CVID.
The above reported case highlights the need for a timely correct diagnosis and treatment of CVID to avoid complications, which could cause recourse to splenectomy, such as in our case or development of malignancies.
American Psychological Association (APA)
Ricciardi, Luisa& Furci, Fabiana& Ieni, A.& Macrì, Antonio. 2019. Castleman Disease in a Patient with Common Variable Immunodeficiency. Case Reports in Immunology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1136878
Modern Language Association (MLA)
Ricciardi, Luisa…[et al.]. Castleman Disease in a Patient with Common Variable Immunodeficiency. Case Reports in Immunology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1136878
American Medical Association (AMA)
Ricciardi, Luisa& Furci, Fabiana& Ieni, A.& Macrì, Antonio. Castleman Disease in a Patient with Common Variable Immunodeficiency. Case Reports in Immunology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1136878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136878