Schisandrin B Prevents Hind Limb from Ischemia-Reperfusion-Induced Oxidative Stress and Inflammation via MAPKNF-κB Pathways in Rats
Joint Authors
Zhu, Ning
Cai, Changhong
Zhou, Aiming
Zhao, Xuyong
Xiang, Yijia
Zeng, Chunlai
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Schisandrin B (ScB), isolated from Schisandra chinensis (S.
chinensis), is a traditional Chinese medicine with proven cardioprotective and neuroprotective effects.
However, it is unclear whether ScB also has beneficial effects on rat hind limb ischemia/reperfusion (I/R) injury model.
In this study, ScB (20 mg/kg, 40 mg/kg, and 80 mg/kg) was administered via oral gavage once daily for 5 days before the surgery.
After 6 h ischemia and 24 h reperfusion of left hind limb, ScB reduced I/R induced histological changes and edema.
ScB also suppressed the oxidative stress through decreasing MDA level and increasing SOD activity.
Moreover, above changes were associated with downregulated TNF-α mRNA expression and reduced level of IL-1β in plasma.
Meanwhile, ScB treatment downregulated activation of p38MAPK, ERK1/2, and NF-κB in ischemic skeletal muscle.
These results demonstrate that ScB treatment could prevent hind limb I/R skeletal muscle injury possibly by attenuating oxidative stress and inflammation via p38MAPK, ERK1/2, and NF-κB pathways.
American Psychological Association (APA)
Zhu, Ning& Cai, Changhong& Zhou, Aiming& Zhao, Xuyong& Xiang, Yijia& Zeng, Chunlai. 2017. Schisandrin B Prevents Hind Limb from Ischemia-Reperfusion-Induced Oxidative Stress and Inflammation via MAPKNF-κB Pathways in Rats. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136890
Modern Language Association (MLA)
Zhu, Ning…[et al.]. Schisandrin B Prevents Hind Limb from Ischemia-Reperfusion-Induced Oxidative Stress and Inflammation via MAPKNF-κB Pathways in Rats. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1136890
American Medical Association (AMA)
Zhu, Ning& Cai, Changhong& Zhou, Aiming& Zhao, Xuyong& Xiang, Yijia& Zeng, Chunlai. Schisandrin B Prevents Hind Limb from Ischemia-Reperfusion-Induced Oxidative Stress and Inflammation via MAPKNF-κB Pathways in Rats. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136890