Cauliflower Mosaic Virus TAV, a Plant Virus Protein That Functions like Ribonuclease H1 and is Cytotoxic to Glioma Cells
Joint Authors
Piccinini, Filippo
Turri, Valentina
Latinovic, Olga S.
Bonafè, Massimiliano
Toyang, Ngeh
Parigi, Maria
Calassanzio, Matteo
Martelli, Pier Luigi
Vagheggini, Alessandro
Abbati, Giulia
Sarnelli, Anna
Casadio, Rita
Ratti, Claudio
Massi, Paola
Schoelz, James E.
Salvato, Maria S.
Martinelli, Giovanni
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recent comparisons between plant and animal viruses reveal many common principles that underlie how all viruses express their genetic material, amplify their genomes, and link virion assembly with replication.
Cauliflower mosaic virus (CaMV) is not infectious for human beings.
Here, we show that CaMV transactivator/viroplasmin protein (TAV) shares sequence similarity with and behaves like the human ribonuclease H1 (RNase H1) in reducing DNA/RNA hybrids detected with S9.6 antibody in HEK293T cells.
We showed that TAV is clearly expressed in the cytosol and in the nuclei of transiently transfected human cells, similar to its distribution in plants.
TAV also showed remarkable cytotoxic effects in U251 human glioma cells in vitro.
These characteristics pave the way for future analysis on the use of the plant virus protein TAV, as an alternative to human RNAse H1 during gene therapy in human cells.
American Psychological Association (APA)
Turri, Valentina& Latinovic, Olga S.& Bonafè, Massimiliano& Toyang, Ngeh& Parigi, Maria& Calassanzio, Matteo…[et al.]. 2020. Cauliflower Mosaic Virus TAV, a Plant Virus Protein That Functions like Ribonuclease H1 and is Cytotoxic to Glioma Cells. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1136893
Modern Language Association (MLA)
Turri, Valentina…[et al.]. Cauliflower Mosaic Virus TAV, a Plant Virus Protein That Functions like Ribonuclease H1 and is Cytotoxic to Glioma Cells. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1136893
American Medical Association (AMA)
Turri, Valentina& Latinovic, Olga S.& Bonafè, Massimiliano& Toyang, Ngeh& Parigi, Maria& Calassanzio, Matteo…[et al.]. Cauliflower Mosaic Virus TAV, a Plant Virus Protein That Functions like Ribonuclease H1 and is Cytotoxic to Glioma Cells. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1136893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136893