The Role of Posttranslational Modifications in DNA Repair
Joint Authors
Liu, Jiejie
Ti, Dongdong
Chen, Deyun
Bai, Miaomiao
Mei, Qian
Wu, Zhiqiang
Han, Weidong
Yan, Xin
Li, Xiang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The human body is a complex structure of cells, which are exposed to many types of stress.
Cells must utilize various mechanisms to protect their DNA from damage caused by metabolic and external sources to maintain genomic integrity and homeostasis and to prevent the development of cancer.
DNA damage inevitably occurs regardless of physiological or abnormal conditions.
In response to DNA damage, signaling pathways are activated to repair the damaged DNA or to induce cell apoptosis.
During the process, posttranslational modifications (PTMs) can be used to modulate enzymatic activities and regulate protein stability, protein localization, and protein-protein interactions.
Thus, PTMs in DNA repair should be studied.
In this review, we will focus on the current understanding of the phosphorylation, poly(ADP-ribosyl)ation, ubiquitination, SUMOylation, acetylation, and methylation of six typical PTMs and summarize PTMs of the key proteins in DNA repair, providing important insight into the role of PTMs in the maintenance of genome stability and contributing to reveal new and selective therapeutic approaches to target cancers.
American Psychological Association (APA)
Bai, Miaomiao& Ti, Dongdong& Mei, Qian& Liu, Jiejie& Yan, Xin& Chen, Deyun…[et al.]. 2020. The Role of Posttranslational Modifications in DNA Repair. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1136913
Modern Language Association (MLA)
Bai, Miaomiao…[et al.]. The Role of Posttranslational Modifications in DNA Repair. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1136913
American Medical Association (AMA)
Bai, Miaomiao& Ti, Dongdong& Mei, Qian& Liu, Jiejie& Yan, Xin& Chen, Deyun…[et al.]. The Role of Posttranslational Modifications in DNA Repair. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1136913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136913