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Leptin Overexpression as a Poor Prognostic Factor for Colorectal Cancer
Joint Authors
Li, Chunxiang
Qiu, Songbo
Li, Chunxiang
Wei, Ran
Zhao, Zhixun
Guan, Xu
Liu, Zheng
Wang, Xishan
Jiang, Zheng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Leptin acts as an adipocytokine functions via the leptin receptor, which stimulates growth, migration, and invasion of cancer cells.
This study is aimed at identifying leptin as a prognostic factor in colorectal cancer (CRC).
The differentially expressed genes with prognostic value in CRC tissues either with or without liver metastasis were assessed based on The Cancer Genomic Atlas (TCGA).
Leptin was considered a candidate gene for further analysis.
Its expression features of 206 CRC patients without liver metastasis and 201 patients with metastasis on tissue microarrays were assessed by immunochemical staining, and the effect of leptin on survival was assessed by Kaplan-Meier analyses.
Overexpressed leptin indicated a poorer prognosis for CRC patients in overall survival (p<0.05, log-rank test) based on the TCGA database.
The leptin expression significantly correlated with metastasis stage (p<.010) and lymph node involvement (p<.010).
Multivariate analysis also indicated that strong leptin expression was an independent adverse prognosticator in CRC (p=.017).
Leptin may be valued as a prognostic marker could contribute to predicting a clinical outcome for patients with CRC.
American Psychological Association (APA)
Li, Chunxiang& Qiu, Songbo& Wei, Ran& Zhao, Zhixun& Guan, Xu& Liu, Zheng…[et al.]. 2020. Leptin Overexpression as a Poor Prognostic Factor for Colorectal Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136952
Modern Language Association (MLA)
Li, Chunxiang…[et al.]. Leptin Overexpression as a Poor Prognostic Factor for Colorectal Cancer. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1136952
American Medical Association (AMA)
Li, Chunxiang& Qiu, Songbo& Wei, Ran& Zhao, Zhixun& Guan, Xu& Liu, Zheng…[et al.]. Leptin Overexpression as a Poor Prognostic Factor for Colorectal Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136952