Immunotherapy in Gastrointestinal Cancers
Joint Authors
Procaccio, Letizia
Schirripa, Marta
Fassan, Matteo
Vecchione, Loredana
Bergamo, Francesca
Prete, Alessandra Anna
Intini, Rossana
Manai, Chiara
Dadduzio, Vincenzo
Boscolo, Alice
Zagonel, Vittorina
Lonardi, Sara
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-03
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Gastrointestinal cancers represent a major public health problem worldwide.
Immunotherapeutic strategies are currently under investigation in this setting and preliminary results of ongoing trials adopting checkpoint inhibitors are striking.
Indeed, although a poor immunogenicity for GI has been reported, a strong biological rationale supports the development of immunotherapy in this field.
The clinical and translational research on immunotherapy for the treatment of GI cancers started firstly with the identification of immune-related mechanisms possibly relevant to GI tumours and secondly with the development of immunotherapy-based agents in clinical trials.
In the present review a general overview is firstly provided followed by a focus on major findings on gastric, colorectal, and hepatocellular carcinomas.
Finally, pathological and molecular perspectives are provided since many efforts are ongoing in order to identify possible predictive biomarkers and to improve patients’ selection.
Many issues are still unsolved in this field; however, we strongly believe that immunotherapy might positively affect the natural history of a subgroup of GI cancer patients improving outcome and the overall quality of life.
American Psychological Association (APA)
Procaccio, Letizia& Schirripa, Marta& Fassan, Matteo& Vecchione, Loredana& Bergamo, Francesca& Prete, Alessandra Anna…[et al.]. 2017. Immunotherapy in Gastrointestinal Cancers. BioMed Research International،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1136994
Modern Language Association (MLA)
Procaccio, Letizia…[et al.]. Immunotherapy in Gastrointestinal Cancers. BioMed Research International No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1136994
American Medical Association (AMA)
Procaccio, Letizia& Schirripa, Marta& Fassan, Matteo& Vecchione, Loredana& Bergamo, Francesca& Prete, Alessandra Anna…[et al.]. Immunotherapy in Gastrointestinal Cancers. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1136994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136994