Protective Role of Coenzyme Q10 in Acute Sepsis-Induced Liver Injury in BALBc Mice
Joint Authors
Liu, Hong-Yang
Hao, Yu-Hua
Li, Qian-wei
Yang, Qin
Wu, Yu-ling
Zhang, Xiao-Qing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Sepsis increases the risk of the liver injury development.
According to the research works, coenzyme Q10 exhibits hepatoprotective properties in vivo as well as in vitro.
Current work aimed at investigating the protective impacts of coenzyme Q10 against liver injury in septic BALB/c mice.
The male BALB/c mice were randomly segregated into 4 groups: the control group, the coenzyme Q10 treatment group, the puncture and cecal ligation group, and the coenzyme Q10+cecal ligation and puncture group.
Cecal ligation and puncture was conducted after gavagaging the mice with coenzyme Q10 during two weeks.
Following 48 h postcecal ligation and puncture, we estimated hepatic biochemical parameters and histopathological changes in hepatic tissue.
We evaluated the expression of factors associated with autophagy, pyroptosis, and inflammation.
Findings indicated that coenzyme Q10 decreased the plasma levels in alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase in the cecal ligation and puncture group.
Coenzyme Q10 significantly inhibited the elevation of sequestosome-1, interleukin-1β, oligomerization domain-like receptor 3 and nucleotide-binding, interleukin-6, and tumor necrosis factor-α expression levels; coenzyme Q10 also increased beclin 1 levels.
Coenzyme Q10 might be a significant agent in the treatment of liver injury induced by sepsis.
American Psychological Association (APA)
Li, Qian-wei& Yang, Qin& Liu, Hong-Yang& Wu, Yu-ling& Hao, Yu-Hua& Zhang, Xiao-Qing. 2020. Protective Role of Coenzyme Q10 in Acute Sepsis-Induced Liver Injury in BALBc Mice. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1137022
Modern Language Association (MLA)
Li, Qian-wei…[et al.]. Protective Role of Coenzyme Q10 in Acute Sepsis-Induced Liver Injury in BALBc Mice. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1137022
American Medical Association (AMA)
Li, Qian-wei& Yang, Qin& Liu, Hong-Yang& Wu, Yu-ling& Hao, Yu-Hua& Zhang, Xiao-Qing. Protective Role of Coenzyme Q10 in Acute Sepsis-Induced Liver Injury in BALBc Mice. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1137022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137022