Evaluation of Grewia ferruginea Hochst ex A. Rich Mucilage as Suspending Agent in Metronidazole Benzoate Suspension
Joint Authors
Sibhat, Gereziher Gebremedhin
Haile, Tsadkan Gebremeskel
Tadese, Ebisa
Tesfay, Desta
Molla, Fantahun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Various species of the genus Grewia have been investigated for different pharmaceutical applications as excipients, yet a study on the potential use of Grewia ferruginea mucilage (GFM) as a suspending agent is lacking.
Thus, this study is aimed at evaluating the efficacy of Grewia ferruginea mucilage (GFM) as a suspending agent in metronidazole benzoate suspension.
The suspensions were prepared using 0.5%, 1%, 1.5%, and 2% w/v of GFM and compared with suspensions prepared from xanthan gum (XGM) and sodium carboxyl methyl cellulose (SCMC) in similar concentrations.
The prepared suspensions were evaluated for visual appearance, pH, rheology, sedimentation volume, redispersibility, degree of flocculation, and in vitro drug release profile.
Stability study was done at different storage conditions for three months.
The results indicated that all the prepared suspension formulations exhibited pseudoplastic flow characteristics with viscosity imparting ability of the suspending agents in the order of XGM>GFM>SCMC (p<0.05).
The flow rate and redispersibility of the formulations prepared with GFM were significantly lower than those with SCMC and higher than those prepared with XGM.
At 0.5% w/v suspending agent concentrations, the sedimentation volume of the formulations was in the order of XGM>GFM>SCMC (p<0.05).
However, at all other concentrations, the sedimentation volume of the formulations prepared with GFM had similar results with XGM but exhibited significantly higher sedimentation volume than SCMC.
The formulations with GFM showed a higher degree of flocculation at 0.5% w/v concentration but were comparable at 1.5% w/v with XGM containing formulations.
The pH, assay, and in vitro release profile of all assessed formulations were within the pharmacopial limit.
Thus, based on the finding of this study, it can be concluded that Grewia ferruginea bark mucilage has the potential to be utilized as a suspending agent in suspension formulations.
American Psychological Association (APA)
Haile, Tsadkan Gebremeskel& Sibhat, Gereziher Gebremedhin& Tadese, Ebisa& Tesfay, Desta& Molla, Fantahun. 2020. Evaluation of Grewia ferruginea Hochst ex A. Rich Mucilage as Suspending Agent in Metronidazole Benzoate Suspension. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137034
Modern Language Association (MLA)
Haile, Tsadkan Gebremeskel…[et al.]. Evaluation of Grewia ferruginea Hochst ex A. Rich Mucilage as Suspending Agent in Metronidazole Benzoate Suspension. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1137034
American Medical Association (AMA)
Haile, Tsadkan Gebremeskel& Sibhat, Gereziher Gebremedhin& Tadese, Ebisa& Tesfay, Desta& Molla, Fantahun. Evaluation of Grewia ferruginea Hochst ex A. Rich Mucilage as Suspending Agent in Metronidazole Benzoate Suspension. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137034