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Mucormycosis Leading to Cerebral Edema and Cerebellar Tonsillar Herniation after Allogeneic Bone Marrow Transplant: A Case Report
Joint Authors
Jeurkar, Chetan
Margetich, Lauren
Sahin, Ziver
Source
Case Reports in Infectious Diseases
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Mucormycosis following hematopoietic stem cell transplant (HSCT) carries a very high mortality rate.
Pulmonary mucormycosis often leads to systemic dissemination and eventual death.
It is imperative for transplant providers to have a high level of suspicion for mucormycosis and initiate early treatment.
Here, we present a 64-year-old woman who died of disseminated mucormycosis 13 days following her allogeneic HSCT.
Case Presentation.
A 64-year-old female with a history of acute myeloid leukemia (AML) presented for allogeneic HSCT and passed away from intracerebral hemorrhage secondary to mucormycosis infection 13 days following her transplant.
On autopsy, it was found she had angioinvasive mucormycosis in her frontal lobe leading to cerebral edema which eventually led to tonsillar herniation and brainstem infarction.
Her lungs were the likely source of infectious dissemination.
Discussion.
This case represents an unusual course of events following HSCT in that no other published case shows tonsillar herniation resulting from mucormycosis-related intracerebral swelling.
We also report this case because it is believed mucormycosis in HSCT patients is underreported.
Additionally, our case highlights the importance of increased vigilance for mucormycosis in patients with prolonged neutropenia prior to HSCT and the potential link of voriconazole prophylaxis and increased risk for mucormycosis.
American Psychological Association (APA)
Jeurkar, Chetan& Margetich, Lauren& Sahin, Ziver. 2019. Mucormycosis Leading to Cerebral Edema and Cerebellar Tonsillar Herniation after Allogeneic Bone Marrow Transplant: A Case Report. Case Reports in Infectious Diseases،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1137035
Modern Language Association (MLA)
Jeurkar, Chetan…[et al.]. Mucormycosis Leading to Cerebral Edema and Cerebellar Tonsillar Herniation after Allogeneic Bone Marrow Transplant: A Case Report. Case Reports in Infectious Diseases No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1137035
American Medical Association (AMA)
Jeurkar, Chetan& Margetich, Lauren& Sahin, Ziver. Mucormycosis Leading to Cerebral Edema and Cerebellar Tonsillar Herniation after Allogeneic Bone Marrow Transplant: A Case Report. Case Reports in Infectious Diseases. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1137035
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137035