Nanoparticulate Tubular Immunostimulating Complexes: Novel Formulation of Effective Adjuvants and Antigen Delivery Systems
Joint Authors
Sanina, Nina
Chopenko, Natalia
Mazeika, Andrey
Kostetsky, Eduard
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
New generation vaccines, based on isolated antigens, are safer than traditional ones, comprising the whole pathogen.
However, major part of purified antigens has weak immunogenicity.
Therefore, elaboration of new adjuvants, more effective and safe, is an urgent problem of vaccinology.
Tubular immunostimulating complexes (TI-complexes) are a new type of nanoparticulate antigen delivery systems with adjuvant activity.
TI-complexes consist of cholesterol and compounds isolated from marine hydrobionts: cucumarioside A2-2 (CDA) from Cucumaria japonica and monogalactosyldiacylglycerol (MGDG) from marine algae or seagrass.
These components were selected due to immunomodulatory and other biological activities.
Glycolipid MGDG from marine macrophytes comprises a high level of polyunsaturated fatty acids (PUFAs), which demonstrate immunomodulatory properties.
CDA is a well-characterized individual compound capable of forming stable complex with cholesterol.
Such complexes do not possess hemolytic activity.
Ultralow doses of cucumariosides stimulate cell as well as humoral immunity.
Therefore, TI-complexes comprising biologically active components turned out to be more effective than the strongest adjuvants: immunostimulating complexes (ISCOMs) and complete Freund’s adjuvant.
In the present review, we discuss results published in series of our articles on elaboration, qualitative and quantitative composition, ultrastructure, and immunostimulating activity of TI-complexes.
The review allows immersion in the history of creating TI-complexes.
American Psychological Association (APA)
Sanina, Nina& Chopenko, Natalia& Mazeika, Andrey& Kostetsky, Eduard. 2017. Nanoparticulate Tubular Immunostimulating Complexes: Novel Formulation of Effective Adjuvants and Antigen Delivery Systems. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137066
Modern Language Association (MLA)
Sanina, Nina…[et al.]. Nanoparticulate Tubular Immunostimulating Complexes: Novel Formulation of Effective Adjuvants and Antigen Delivery Systems. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1137066
American Medical Association (AMA)
Sanina, Nina& Chopenko, Natalia& Mazeika, Andrey& Kostetsky, Eduard. Nanoparticulate Tubular Immunostimulating Complexes: Novel Formulation of Effective Adjuvants and Antigen Delivery Systems. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137066