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Determinants of Risk Factors for Renal Impairment among HIV-Infected Patients Treated with Tenofovir Disoproxil Fumarate-Based Antiretroviral Regimen in Southern Vietnam
Joint Authors
Hoang, Cuong Q.
Nguyen, Hai D.
Vu, Huy Q.
Phan, Lan T.
Linh, Hoang Thuy
Nguyen, Khai T
Ly, Hong
Tat, Thang D
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The situation of renal impairment among HIV-infected patients treated with TDF-based antiretroviral (ARV) regimen greater than 3 years is little known when TDF use has been promptly increasing in Vietnam.
Methods.
We analyse demographic and clinical data from a cross-sectional survey of 400 HIV-infected patients aged ≥18 years, who were treatment-naive or switched TDF regimen within over 3 years between November 2018 and March 2019.
Serological tests for serum creatinine, ALT, and AST were performed.
Renal impairment was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2.
Multivariate regression analyses were used to explore the risk factors associated with renal impairment.
Results.
At the baseline, 7.8% of respondents had estimated glomerular filtration rate (eGFR) of 30–59 mL/min/1.73 m2 and 0.8% had eGFR of 15–29 mL/min/1.73 m2, out of 34 (8.5%) of participants who had renal impairment.
Multivariate analysis showed that participants who had preexposure to isoniazid (adjusted PR [aPR] = 0.35 Cl: 0.14–0.91) compared with nonexposure to isoniazid who had a BMI from 18.5 up to 25 kg/m2 (aPR = 0.31 Cl: 0.15–0.62) compared with BMI below 18.5 kg/m2 were less likely to suffer from renal impairment.
Patients aged greater than 60 years (aPR = 26.75, 95% Cl: 3.38–211.62) compared with those aged 20–29 years were more likely to have increased risk of renal impairment.
Conclusion.
Our findings underscore the need for longitudinal studies to assess the influence of TDF on maintaining the low prevalence of renal impairment among HIV-infected patients in Vietnam.
American Psychological Association (APA)
Hoang, Cuong Q.& Nguyen, Hai D.& Vu, Huy Q.& Nguyen, Khai T& Linh, Hoang Thuy& Ly, Hong…[et al.]. 2020. Determinants of Risk Factors for Renal Impairment among HIV-Infected Patients Treated with Tenofovir Disoproxil Fumarate-Based Antiretroviral Regimen in Southern Vietnam. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1137112
Modern Language Association (MLA)
Hoang, Cuong Q.…[et al.]. Determinants of Risk Factors for Renal Impairment among HIV-Infected Patients Treated with Tenofovir Disoproxil Fumarate-Based Antiretroviral Regimen in Southern Vietnam. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1137112
American Medical Association (AMA)
Hoang, Cuong Q.& Nguyen, Hai D.& Vu, Huy Q.& Nguyen, Khai T& Linh, Hoang Thuy& Ly, Hong…[et al.]. Determinants of Risk Factors for Renal Impairment among HIV-Infected Patients Treated with Tenofovir Disoproxil Fumarate-Based Antiretroviral Regimen in Southern Vietnam. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1137112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137112