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An Italian Case of Disseminated Histoplasmosis Associated with HIV
Joint Authors
Pasticci, Maria Bruna
Papalini, Chiara
Belfiori, Barbara
Martino, Giovanni
Papili, Rita
Pitzurra, Lucia
Ascani, Stefano
Source
Case Reports in Infectious Diseases
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Histoplasma capsulatum is a dimorphic fungus, endemic in the Americas, Africa (var.
duboisii), India, and Southeast Asia.
H.
capsulatum infection is rarely diagnosed in Italy, while in Latin America, progressive disseminated histoplasmosis (PDH) is one of the most frequent AIDS-defining illnesses and causes of AIDS-related deaths.
We report a case of PDH and new HIV infection diagnosis in a Cuban patient, who has been living in Italy for the past 10 years.
Bone marrow aspirate and peripheral blood smear microscopy suggested H.
capsulatum infection.
The diagnosis was confirmed with the culture method identifying its thermal dimorphism.
Liposomal amphotericin B was administered alone for 10 days and then for another 2 days, accompanied with voriconazole; the former was stopped for probable side effects (persistent fever and worsening thrombocytopenia), and voriconazole was continued to complete 4 weeks.
PDH maintenance treatment consisted of itraconazole for one year.
Antiretroviral therapy (ART) was started on the third week of antifungal treatment.
At the 3-year follow-up, the patient is adherent on ART, the virus was suppressed, and she has an optimal immune recovery.
This case highlights the need to suspect histoplasmosis in the differential diagnosis of opportunistic infections in immunocompromised persons, native to or who have traveled to endemic countries.
American Psychological Association (APA)
Papalini, Chiara& Belfiori, Barbara& Martino, Giovanni& Papili, Rita& Pitzurra, Lucia& Ascani, Stefano…[et al.]. 2019. An Italian Case of Disseminated Histoplasmosis Associated with HIV. Case Reports in Infectious Diseases،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1137118
Modern Language Association (MLA)
Papalini, Chiara…[et al.]. An Italian Case of Disseminated Histoplasmosis Associated with HIV. Case Reports in Infectious Diseases No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1137118
American Medical Association (AMA)
Papalini, Chiara& Belfiori, Barbara& Martino, Giovanni& Papili, Rita& Pitzurra, Lucia& Ascani, Stefano…[et al.]. An Italian Case of Disseminated Histoplasmosis Associated with HIV. Case Reports in Infectious Diseases. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1137118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137118