The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer
Joint Authors
Zheng, Ruoyi
Chen, Wenming
Xia, Weiting
Zheng, Jingyu
Zhou, Qing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Purpose.
To assess the expression of insulin-like growth factor binding protein (IGFBP) family and its prognostic impact in ovarian cancer (OC) patients.
Materials and Methods.
The mRNA expression and protein expression of individual IGFBPs in healthy ovarian samples and OC tissues were explored through Oncomine, Gene Expression Profiling Interactive Analysis, and Human Protein Atlas database.
Additionally, the prognostic values of the six IGFBP members in patients with OC were evaluated by Kaplan-Meier plotter.
Results.
IGFBP2 and IGFBP4 mRNA expression were remarkably upregulated in patients with OC.
To be specific, the mRNA expression of IGFBP2 was upregulated in patients with serous ovarian cancer (SOC), while IGFBP1/3/4/5/6 mRNA levels were downregulated.
In addition, the IGFBP4 protein expression was upregulated in SOC, and the IGFBP6 protein expression was upregulated in both of SOC and endometrioid ovarian cancer (EOC) tissues.
High IGFBP1 mRNA levels showed favorable overall survival (OS) and progression-free survival (PFS) in all OC.
Meanwhile, increased IGFBP5/6 mRNA levels revealed worsen OS and PFS in all OC patients.
IGFBP4/6 mRNA levels predicted unfavorable OS and PFS only in SOC patients.
Moreover, the aberrant mRNA expression of IGFBP1/2/4/5/6 was correlated with significantly prognosis in patients receiving different chemotherapeutic regimens.
Conclusion.
This study indicates that the IGFBP family reveals distinct prognosis in patients with OC.
IGFBP1/2/4/5/6 are useful prognostic predictors for chemotherapeutic effect in OC patients, and IGFBP2/4 are potential tumor markers for the diagnosis of OC.
American Psychological Association (APA)
Zheng, Ruoyi& Chen, Wenming& Xia, Weiting& Zheng, Jingyu& Zhou, Qing. 2020. The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1137132
Modern Language Association (MLA)
Zheng, Ruoyi…[et al.]. The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1137132
American Medical Association (AMA)
Zheng, Ruoyi& Chen, Wenming& Xia, Weiting& Zheng, Jingyu& Zhou, Qing. The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1137132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137132