![](/images/graphics-bg.png)
EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3KAkt Pathway
Joint Authors
Xie, Cheng
Zhou, Mingfeng
Lin, Jie
Wu, Zhiyong
Ding, Shengfeng
Luo, Jie
Zhan, Zhengming
Cai, Yonghua
Xue, Shuaishuai
Song, Ye
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Eukaryotic translation elongation factor 1δ (EEF1D), a subunit of the elongation factor 1 complex of proteins, mediates the elongation process of protein synthesis.
Besides this canonical role, EEF1D was found overexpressed in many tumors, like hepatocarcinomas and medulloblastomas.
In the present study, we demonstrated for the first time that EEF1D may interact with other putative proteins to regulate cell proliferation, migration, and invasion through PI3K/Akt and EMT pathways in glioma.
Furthermore, knockdown of EEF1D could reduce cell proliferation and impaired epithelial-mesenchymal transition (EMT) phenotypes, including cell invasion.
Taken together, these results indicate that EEF1D and its partner proteins might play a critical role in glioma and serve as a potential therapeutic target of glioma.
American Psychological Association (APA)
Xie, Cheng& Zhou, Mingfeng& Lin, Jie& Wu, Zhiyong& Ding, Shengfeng& Luo, Jie…[et al.]. 2020. EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3KAkt Pathway. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137154
Modern Language Association (MLA)
Xie, Cheng…[et al.]. EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3KAkt Pathway. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1137154
American Medical Association (AMA)
Xie, Cheng& Zhou, Mingfeng& Lin, Jie& Wu, Zhiyong& Ding, Shengfeng& Luo, Jie…[et al.]. EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3KAkt Pathway. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137154