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SOCS1 Regulates Apoptosis and Inflammation by Inhibiting IL-4 Signaling in IL-1β-Stimulated Human Osteoarthritic Chondrocytes
Joint Authors
Lei, Wei
Ma, Jianbing
He, Qiang
Sun, Caihong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Recently, Suppressor of Cytokine Signaling 1 (SOCS1) was identified as a potential therapeutic target for osteoarthritis (OA) treatment.
However, the mechanisms and signaling pathways of SOCS1 in the regulation of OA development are unclear.
The purpose of the current study was to investigate whether interleukin- (IL-) 4 was involved in regulatory mechanism of SOCS1 in human osteoarthritic chondrocytes.
First, IL-1β was used to stimulate human osteoarthritic chondrocytes isolated from the articular cartilage of OA patients undergoing total knee replacement.
The protein and mRNA expression levels of SOCS1 were upregulated in IL-1β-stimulated human osteoarthritic chondrocytes compared with control cells.
The knockdown of SOCS1 increased cell viability and inhibited cell apoptosis.
It was also found that IL-4 expression was increased by SOCS1 silencing.
Additionally, knockdown of IL-4 reduced cell viability and increased cell apoptosis of osteoarthritic chondrocytes transfected with SOCS1 siRNA.
Moreover, the decreased expression of inflammatory factors induced by SOCS1 was enhanced by IL-4 knockdown.
In conclusion, IL-4 signaling plays a crucial role in the regulatory functions of SOCS1 in apoptosis and inflammation in human osteoarthritic chondrocytes.
These findings provide a potential therapeutic target for the clinical treatment of OA.
American Psychological Association (APA)
He, Qiang& Sun, Caihong& Lei, Wei& Ma, Jianbing. 2017. SOCS1 Regulates Apoptosis and Inflammation by Inhibiting IL-4 Signaling in IL-1β-Stimulated Human Osteoarthritic Chondrocytes. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137167
Modern Language Association (MLA)
He, Qiang…[et al.]. SOCS1 Regulates Apoptosis and Inflammation by Inhibiting IL-4 Signaling in IL-1β-Stimulated Human Osteoarthritic Chondrocytes. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1137167
American Medical Association (AMA)
He, Qiang& Sun, Caihong& Lei, Wei& Ma, Jianbing. SOCS1 Regulates Apoptosis and Inflammation by Inhibiting IL-4 Signaling in IL-1β-Stimulated Human Osteoarthritic Chondrocytes. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137167