THAP11 Functions as a Tumor Suppressor in Gastric Cancer through Regulating c-Myc Signaling Pathways
Joint Authors
Du, Juan
Xue, Wanjuan
Wang, Yu
Wei, Yameng
Zhang, Huahua
Gao, Yi
Li, Dan
Feng, Yun
Yan, Jing
Zhang, Jing
Han, Jiming
Shi, Haiyan
Wang, Fenghui
Li, Jia
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We aim to investigate the role of THAP11 (thanatos-associated protein11) in gastric cancer and its regulation mechanisms.
THAP11 expression was analyzed in 51 pairs of GC tissues and the corresponding paracancerous tissues by qRT-PCR and Western blot.
After THAP11 was overexpressed or knocked-down, cell proliferation, cell cycle, and apoptosis were detected in MKN-45 cells.
We found that THAP11 was significantly downregulated in GC tissues and GC cell lines.
Functionally, THAP11 overexpression markedly inhibited cell growth, induced G1/G0 cell-cycle arrest, and promoted cell apoptosis of MKN-45 cells, while silencing of THAP11 led to increased cell growth, increased DNA synthesis, and inhibited apoptosis.
In addition, THAP11 negatively regulated the expression of c-Myc, decreased cyclinD1 protein, and increased p27 and p21 protein levels.
We also found cell growth suppression induced by THAP11 was rescued by c-Myc overexpression, further confirming that THAP11 suppresses gastric cancer cell growth via the c-Myc pathway.
THAP11 acts as a cell growth suppressor and exerts its role possibly through negatively regulating c-Myc pathway in gastric cancer.
American Psychological Association (APA)
Zhang, Jing& Zhang, Huahua& Shi, Haiyan& Wang, Fenghui& Du, Juan& Wang, Yu…[et al.]. 2020. THAP11 Functions as a Tumor Suppressor in Gastric Cancer through Regulating c-Myc Signaling Pathways. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137189
Modern Language Association (MLA)
Zhang, Jing…[et al.]. THAP11 Functions as a Tumor Suppressor in Gastric Cancer through Regulating c-Myc Signaling Pathways. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1137189
American Medical Association (AMA)
Zhang, Jing& Zhang, Huahua& Shi, Haiyan& Wang, Fenghui& Du, Juan& Wang, Yu…[et al.]. THAP11 Functions as a Tumor Suppressor in Gastric Cancer through Regulating c-Myc Signaling Pathways. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137189