Bisphenol A Is More Potent than Phthalate Metabolites in Reducing Pancreatic β-Cell Function
Joint Authors
Holme, Jørn A.
Nygaard, Unni Cecilie
Bodin, Johanna
Weldingh, Nina Mickelson
Jørgensen-Kaur, Lena
Becher, Rune
Bølling, Anette Kocbach
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Bisphenol A (BPA) and phthalates are common environmental contaminants that have been proposed to influence incidence and development of types 1 and 2 diabetes.
Thus, effects of BPA and three phthalate metabolites (monoisobutyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), and mono-(2-ethylhexyl) phthalate (MEHP)) were studied in the pancreatic β-cell line INS-1E, after 2–72 h of exposure to 5–500 μM.
Three endpoints relevant to accelerated development of types 1 or 2 diabetes were investigated: β-cell viability, glucose-induced insulin secretion, and β-cell susceptibility to cytokine-induced cell death.
BPA and the phthalate metabolites reduced cellular viability after 72 h of exposure, with BPA as the most potent chemical.
Moreover, BPA, MEHP, and MnBP increased insulin secretion after 2 h of simultaneous exposure to chemicals and glucose, with potency BPA > MEHP > MnBP.
Longer chemical exposures (24–72 h) showed no consistent effects on glucose-induced insulin secretion, and none of the environmental chemicals affected susceptibility to cytokine-induced cell death.
Overall, BPA was more potent than the investigated phthalate metabolites in affecting insulin secretion and viability in the INS-1E pancreatic β-cells.
In contrast to recent literature, concentrations with relevance to human exposures (1–500 nM) did not affect the investigated endpoints, suggesting that this experimental model displayed relatively low sensitivity to environmental chemical exposure.
American Psychological Association (APA)
Weldingh, Nina Mickelson& Jørgensen-Kaur, Lena& Becher, Rune& Holme, Jørn A.& Bodin, Johanna& Nygaard, Unni Cecilie…[et al.]. 2017. Bisphenol A Is More Potent than Phthalate Metabolites in Reducing Pancreatic β-Cell Function. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137195
Modern Language Association (MLA)
Weldingh, Nina Mickelson…[et al.]. Bisphenol A Is More Potent than Phthalate Metabolites in Reducing Pancreatic β-Cell Function. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1137195
American Medical Association (AMA)
Weldingh, Nina Mickelson& Jørgensen-Kaur, Lena& Becher, Rune& Holme, Jørn A.& Bodin, Johanna& Nygaard, Unni Cecilie…[et al.]. Bisphenol A Is More Potent than Phthalate Metabolites in Reducing Pancreatic β-Cell Function. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137195