Effects of Astaxanthin on Reverse Cholesterol Transport and Atherosclerosis in Mice
Joint Authors
Wu, Hongfu
Zou, Tangbin
Zhu, Shan-Shan
Luo, Fei
Li, Wei-Qiao
Sun, Xue-Rong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
High plasma level of HDL-cholesterol (HDL-C) has been consistently associated with a decreased risk of atherosclerosis (AS); thus, HDL-C is considered to be an antiatherogenic lipoprotein.
The development of novel therapies to enhance the atheroprotective properties of HDL may have the possibility of further reducing the residual AS risk.
Reverse cholesterol transport (RCT) is believed to be a primary atheroprotective activity of HDL, which has been shown to promote the efflux of excess cholesterol from macrophage-derived foam cells via ATP-binding cassette transporter A1 (ABCA1), ATP-binding cassette transporter G1 (ABCG1), and scavenger receptor class B type I (SR-BI) and then transport it back to the liver for excretion into bile and eventually into the feces.
In the current study, we investigated the effects of astaxanthin on RCT and AS progression in mice.
The results showed that short- and long-term supplementation of astaxanthin promote RCT in C57BL/6J and ApoE−/− mice, respectively.
Moreover, astaxanthin can relieve the plaque area of the aortic sinus and aortic cholesterol in mice.
These findings suggest that astaxanthin is beneficial for boosting RCT and preventing the development of AS.
American Psychological Association (APA)
Zou, Tangbin& Zhu, Shan-Shan& Luo, Fei& Li, Wei-Qiao& Sun, Xue-Rong& Wu, Hongfu. 2017. Effects of Astaxanthin on Reverse Cholesterol Transport and Atherosclerosis in Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1137206
Modern Language Association (MLA)
Zou, Tangbin…[et al.]. Effects of Astaxanthin on Reverse Cholesterol Transport and Atherosclerosis in Mice. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1137206
American Medical Association (AMA)
Zou, Tangbin& Zhu, Shan-Shan& Luo, Fei& Li, Wei-Qiao& Sun, Xue-Rong& Wu, Hongfu. Effects of Astaxanthin on Reverse Cholesterol Transport and Atherosclerosis in Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1137206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137206