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Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2
Joint Authors
Song, Hongming
Hua, Kaiyao
Fang, Lin
Wu, Tianqi
Xie, Dan
Hu, Jiashu
Deng, Yijun
Ji, Changle
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Triple-negative breast cancer (TNBC) is the most aggressive subtypes of breast cancer, which has few effective targeted therapies.
Various sources of evidence confirm that microRNAs (miRNAs) contribute to the progression and metastasis of human breast cancer.
However, the molecular mechanisms underlying the changes in miRNAs expression and the regulation of miRNAs functions have not been well clarified.
In this study, we found that the expression of miR-30b-5p was upregulated in breast cancer tissues and breast cancer cell lines, compared to paracancer tissues and normal breast cell lines.
Moreover, induced overexpression of miR-30b-5p promoted the MDA-MB-231 and HCC 1937 cell growth, migration, and invasion and reduced the cellular apoptosis.
Further studies confirmed that miR-30b-5p could directly target ASPP2 and then activate the AKT signaling pathway.
Our results suggested that miR-30b-5p could act as a tumor promoter in TNBC.
The newly identified miR-30b-5p/ASPP2/AKT axis represents a novel therapeutic strategy for treating TNBC.
American Psychological Association (APA)
Wu, Tianqi& Song, Hongming& Xie, Dan& Hua, Kaiyao& Hu, Jiashu& Deng, Yijun…[et al.]. 2020. Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137221
Modern Language Association (MLA)
Wu, Tianqi…[et al.]. Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1137221
American Medical Association (AMA)
Wu, Tianqi& Song, Hongming& Xie, Dan& Hua, Kaiyao& Hu, Jiashu& Deng, Yijun…[et al.]. Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137221