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Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer
Joint Authors
Kim, Chi Kyung
Kim, Tae Jung
Ko, Sang-Bae
Nam, Ki-Woong
An, Sang Joon
Oh, Kyungmi
Yoon, Byung Woo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Ischemic stroke patients with active cancer are known to have poor clinical outcomes.
However, the efficacy and safety of intravenous alteplase (IV t-PA) in this group are still unclear.
In this study, we aimed to evaluate whether stroke patients with cancer had poor clinical outcomes after use of IV t-PA.
We reviewed ischemic stroke patients with active cancer treated with isolated IV t-PA between April 2010 and March 2015 at three national university hospitals from the registry for ischemic stroke in Korea.
The clinical outcomes of early neurological deterioration (END), hemorrhagic transformation, in-hospital mortality, 3-month modified Rankin scale (mRS), the National Institutes of Health Stroke Scale (NIHSS) discharge score, and duration of hospitalization were compared.
We enrolled a total of 12 patients, and the cohort showed poor outcomes including 4 (33%) END events, 7 (58%) hemorrhagic transformations, 3 (25%) in-hospital mortality cases, and 7 (58%) poor mRS (3–6) scores.
Additionally, the cryptogenic stroke group (n = 6) more frequently had high mRS scores (P = 0.043) as well as tendencies for frequent END events, hemorrhagic transformations, in-hospital mortality cases, and higher discharge NIHSS scores without statistical significance.
In conclusion, ischemic stroke patients with active cancer, especially those with a cryptogenic mechanism, showed poor clinical outcomes after use of IV t-PA.
American Psychological Association (APA)
Nam, Ki-Woong& Kim, Chi Kyung& Kim, Tae Jung& An, Sang Joon& Oh, Kyungmi& Ko, Sang-Bae…[et al.]. 2017. Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1137228
Modern Language Association (MLA)
Nam, Ki-Woong…[et al.]. Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1137228
American Medical Association (AMA)
Nam, Ki-Woong& Kim, Chi Kyung& Kim, Tae Jung& An, Sang Joon& Oh, Kyungmi& Ko, Sang-Bae…[et al.]. Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1137228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137228