Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone
Joint Authors
Lima, Maysa Bruno de
Gama, Loyane Almeida
Hauschildt, Andrieli Taise
Dall’Agnol, Denize Jussara Rupolo
Corá, Luciana Aparecida
Americo, Madileine Francely
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Our aim was to verify the effects of prednisone related to gastrointestinal motility, intestinal histology, and mucosal mast cells in rats.
Two-month-old male Wistar rats were randomly assigned to control group (vehicle) animals receiving saline 0.9% (n=7) or treated orally with 0.625 mg/kg/day of prednisone (n=7) or 2.5 mg/kg/day of prednisone (n=7) during 15 days.
Mast cells and other histologic analyses were performed in order to correlate to gastric emptying, cecum arrival, and small intestine transit evaluated by Alternating Current Biosusceptometry.
Results showed that prednisone in adult rats increased the frequency of gastric contractions, hastened gastric emptying, slowed small intestinal transit, and reduced mucosal mast cells.
Histologically, the treatment with both doses of prednisone decreased villus height, whereas longitudinal and circular muscles and crypt depth were not affected.
These findings indicate an impairment of intestinal absorption which may be linked to several GI dysfunctions and symptoms.
The relationship between gastrointestinal motor disorders and cellular immunity needs to be clarified in experimental studies since prednisone is one of the most prescribed glucocorticoids worldwide.
American Psychological Association (APA)
Lima, Maysa Bruno de& Gama, Loyane Almeida& Hauschildt, Andrieli Taise& Dall’Agnol, Denize Jussara Rupolo& Corá, Luciana Aparecida& Americo, Madileine Francely. 2017. Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137239
Modern Language Association (MLA)
Lima, Maysa Bruno de…[et al.]. Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137239
American Medical Association (AMA)
Lima, Maysa Bruno de& Gama, Loyane Almeida& Hauschildt, Andrieli Taise& Dall’Agnol, Denize Jussara Rupolo& Corá, Luciana Aparecida& Americo, Madileine Francely. Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137239