Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI
Joint Authors
Patel, Chinmay
Thompson, Courtney
Copley-Harris, Megan
Hattab, Yousef
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-26
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
We report a case of rhabdomyolysis and severe acute kidney injury (AKI) requiring dialysis in a 69-year-old male who was recently started on sitagliptin while on chronic simvastatin therapy.
This potential interaction is not included in the package insert for sitagliptin.
A comprehensive literature review revealed six previous reports of rhabdomyolysis due to drug interaction between sitagliptin and statins including simvastatin, lovastatin, and atorvastatin.
Of these six cases, only two had developed rhabdomyolysis-associated AKI, none of which were severe enough to require dialysis.
As patients are commonly prescribed statins and sitagliptin for treatment of dyslipidemia and diabetes, health care professionals should be aware of this potential drug interaction and closely monitor their patients for signs and symptoms of rhabdomyolysis and AKI.
This case highlights the importance of conducting further studies on the risk of muscular toxicity of sitagliptin especially when administered concurrently with statins.
American Psychological Association (APA)
Patel, Chinmay& Thompson, Courtney& Copley-Harris, Megan& Hattab, Yousef. 2019. Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI. Case Reports in Medicine،Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1137256
Modern Language Association (MLA)
Patel, Chinmay…[et al.]. Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI. Case Reports in Medicine No. 2019 (2019), pp.1-3.
https://search.emarefa.net/detail/BIM-1137256
American Medical Association (AMA)
Patel, Chinmay& Thompson, Courtney& Copley-Harris, Megan& Hattab, Yousef. Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI. Case Reports in Medicine. 2019. Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1137256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137256