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Antibody-Negative Relapse of Goodpasture Syndrome with Pulmonary Hemorrhage
Joint Authors
Rohm, Charlene L.
Acree, Sara
Shrivastava, Aseem
Saberi, Asif A.
Lovett, Louis
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Goodpasture syndrome is a rare autoimmune disease comprising antiglomerular basement membrane (anti-GBM) crescentic glomerulonephritis and pulmonary capillaritis with circulating anti-GBM antibodies.
Rarely, antibody-negative cases have been described.
We report a young, African American adult woman admitted with flank pain and hematuria with laboratory testing and kidney biopsy demonstrating anti-GBM crescentic glomerulonephritis with elevated anti-GBM antibody levels.
She received treatment but remained dialysis-dependent.
She was seronegative and clinically stable until she presented 8 months later with dyspnea and hemoptysis requiring mechanical ventilation.
Bronchoscopy revealed diffuse alveolar hemorrhage.
She was treated for relapse of Goodpasture syndrome.
However, anti-GBM antibodies were undetectable.
This case emphasizes prompt diagnosis and treatment of Goodpasture syndrome to preserve renal function.
Additionally, clinical manifestations of Goodpasture syndrome and its degree of activity do not necessarily correlate with the actual antibody titer on relapse.
Clinicians should have enhanced awareness of this atypical presentation of a rare disease.
American Psychological Association (APA)
Rohm, Charlene L.& Acree, Sara& Shrivastava, Aseem& Saberi, Asif A.& Lovett, Louis. 2019. Antibody-Negative Relapse of Goodpasture Syndrome with Pulmonary Hemorrhage. Case Reports in Medicine،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1137270
Modern Language Association (MLA)
Rohm, Charlene L.…[et al.]. Antibody-Negative Relapse of Goodpasture Syndrome with Pulmonary Hemorrhage. Case Reports in Medicine No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1137270
American Medical Association (AMA)
Rohm, Charlene L.& Acree, Sara& Shrivastava, Aseem& Saberi, Asif A.& Lovett, Louis. Antibody-Negative Relapse of Goodpasture Syndrome with Pulmonary Hemorrhage. Case Reports in Medicine. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1137270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137270