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Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review
Joint Authors
Anagnostakos, Konstantinos
Meyer, Christof
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Knowledge about the elution from antibiotic-loaded cement spacers is an indispensable premise for guarantee of clinical success.
A systematic literature search was performed through PubMed.
Search terms were “antibiotic elution” and “antibiotic release” in combination with “spacer,” “hip spacer,” and “knee spacer,” respectively.
A total of 11 studies could be identified.
Seven studies reported on the release of antibiotics after spacer implantation, three studies at spacer removal, and one study on both time points.
Seven studies reported on hip spacers, one study on knee spacers, and three studies on both.
In eight studies, custom-made spacers have been implanted and in three prefabricated ones.
In the majority of the studies, the cement has been loaded with an antibiotic combination, mostly consisting of aminoglycoside (either gentamicin or tobramycin) and vancomycin.
Measured concentrations exceeded the minimal inhibitory concentration of the particular pathogen organisms in each case.
However, large discrepancies were observed with regard to the height of the antibiotic concentration depending on the antibiotic combination and the antibiotic ratio used.
Current literature data indicate a sufficient elution of antibiotics after spacer implantation and at spacer removal, respectively.
Future studies are required to optimize the local antibiotic therapy at the site of spacer implantation.
American Psychological Association (APA)
Anagnostakos, Konstantinos& Meyer, Christof. 2017. Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137277
Modern Language Association (MLA)
Anagnostakos, Konstantinos& Meyer, Christof. Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1137277
American Medical Association (AMA)
Anagnostakos, Konstantinos& Meyer, Christof. Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137277