Thyroid Function in 35 Patients with Gitelman Syndrome
Joint Authors
Ren, Yan
Li, Yuanmei
Zhou, Hong
Lu, Chunyan
Tian, Haoming
Chen, Tao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
In this study, we aimed to analyze thyroid function and related risk factors for thyroid dysfunction in 35 patients with Gitelman syndrome (GS).
Methods.
This study included 35 patients with GS who were referred to West China Hospital of Sichuan University from Aug 2013 to Jan 2018.
General patient characteristics were collected, and thyroid function was assessed.
To evaluate the potential contribution of hypokalemia to thyroid dysfunction, 636 patients who were clinically diagnosed with primary aldosteronism (PA) during the same period were included as the control group; these patients were divided into a hypokalemia group (N=528) and a normokalemia group (N=108).
Logistic regression was used to screen for significant determinants of thyroid dysfunction in the GS patients.
Results.
Patients with GS had a significantly different prevalence of subclinical hypothyroidism, hypothyroidism, and hyperthyroidism than patients with hypokalemic PA and normokalemic PA (28.6%, 2.9%, and 11.4% vs.
15.5%, 6.1%, and 0.7% vs.
8.3%, 4.6%, and 2.8%, P<0.001).
No significant difference was observed in the distribution of thyroid function between the hypokalemic PA group and the normokalemic PA group (P>0.05).
No significant differences were seen in the positive rates of thyrotropin receptor antibody (TRAb), thyroglobulin antibody (TGAb), and thyroid peroxidase antibody (TPOAb) among the three groups (P>0.05).
In the logistic regression, only sex (OR, 7.4; 95% CI, 1.555-35.479; P=0.012) was significantly correlated with thyroid dysfunction in GS patients.
Conclusion.
GS is complicated with a greater rate of thyroid dysfunction than primary aldosteronism.
The risk of thyroid dysfunction in female patients with GS is higher than that in male patients.
American Psychological Association (APA)
Zhou, Hong& Ren, Yan& Lu, Chunyan& Li, Yuanmei& Tian, Haoming& Chen, Tao. 2020. Thyroid Function in 35 Patients with Gitelman Syndrome. BioMed Research International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1137294
Modern Language Association (MLA)
Zhou, Hong…[et al.]. Thyroid Function in 35 Patients with Gitelman Syndrome. BioMed Research International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1137294
American Medical Association (AMA)
Zhou, Hong& Ren, Yan& Lu, Chunyan& Li, Yuanmei& Tian, Haoming& Chen, Tao. Thyroid Function in 35 Patients with Gitelman Syndrome. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1137294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137294