![](/images/graphics-bg.png)
JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma
Joint Authors
Ding, Ling
Yu, Yue
Meng, Lingkai
Li, Wang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-06
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Stomach adenocarcinoma (STAD) is one of the most common malignant tumors.
The Janus kinases (JAKs) play a significant part in cellular biological process, inflammation, and immunity.
The roles of JAKs in STAD are still not systematically described.
Methods.
A series of bioinformatics tools were used to clarify the role of JAKs in STAD.
Results.
JAK3/TYK2 levels were significantly increased in STAD during subgroup analyses based on gender, tumor grade, cancer stages, and nodal metastasis status.
STAD patients with high levels of JAK3/TYK2 had poor overall survival, postprogression survival, and first progression.
Immune infiltration revealed a significant correlation between JAK3/TYK2 expression and the abundance of immune cells as well as immune biomarker expression in STAD.
JAK3/TYK2 was associated with the adaptive immune response, chemokine signaling pathway, and JAK-STAT signaling pathway.
Conclusions.
JAK3 and TYK2 serve as prognostic biomarkers and are associated with immune infiltration in STAD.
American Psychological Association (APA)
Meng, Lingkai& Ding, Ling& Yu, Yue& Li, Wang. 2020. JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1137298
Modern Language Association (MLA)
Meng, Lingkai…[et al.]. JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1137298
American Medical Association (AMA)
Meng, Lingkai& Ding, Ling& Yu, Yue& Li, Wang. JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1137298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137298