Urinary Neutrophil Gelatinase-Associated Lipocalin Is Complementary to Albuminuria in Diagnosis of Early-Stage Diabetic Kidney Disease in Type 2 Diabetes
Joint Authors
Kuśnierz-Cabala, Beata
Kuźniewski, Marek
Żyłka, Agnieszka
Gala-Błądzińska, Agnieszka
Drozdz, Ryszard
Rybak, Katarzyna
Dumnicka, Paulina
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Two clinical phenotypes of diabetic kidney disease (DKD) have been reported, that is, with or without increased albuminuria.
The aim of study was to assess the usefulness of urinary neutrophil gelatinase-associated lipocalin (uNGAL) for the early diagnosis of DKD in the type 2 diabetes mellitus (T2DM).
Methods.
The study group consisted of 123 patients with T2DM (mean age 62 ± 14 years), with urine albumin/creatinine ratio (uACR) < 300 mg/g and eGFR ≥ 60 ml/min/1.73 m2.
The control group included 22 nondiabetic patients with comparable age, sex, and comorbidities.
uNGAL, albumin, and creatinine were measured in the first morning urine samples.
uACR and uNGAL/creatinine ratios (uNCR) were calculated.
Results.
In the control group, maximum uNCR was 39.64 µg/g.
In T2DM group, 24 patients (20%) had higher results, with the maximum value of 378.6 µg/g.
Among patients with uNCR > 39.64 µg/g, 13 (54%) did not have markedly increased albuminuria.
Women with T2DM had higher uNCR than men (p<0.001), without difference in uACR (p=0.09).
uNCR in T2DM patients correlated significantly with HbA1c.
Sex, total cholesterol, and uACR were independent predictors of uNCR above 39.64 µg/g.
Conclusions.
Increased uNGAL and uNCR may indicate early tubular damage, associated with dyslipidemia and worse diabetes control, especially in females with T2DM.
American Psychological Association (APA)
Gala-Błądzińska, Agnieszka& Dumnicka, Paulina& Kuśnierz-Cabala, Beata& Rybak, Katarzyna& Drozdz, Ryszard& Żyłka, Agnieszka…[et al.]. 2017. Urinary Neutrophil Gelatinase-Associated Lipocalin Is Complementary to Albuminuria in Diagnosis of Early-Stage Diabetic Kidney Disease in Type 2 Diabetes. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137310
Modern Language Association (MLA)
Gala-Błądzińska, Agnieszka…[et al.]. Urinary Neutrophil Gelatinase-Associated Lipocalin Is Complementary to Albuminuria in Diagnosis of Early-Stage Diabetic Kidney Disease in Type 2 Diabetes. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1137310
American Medical Association (AMA)
Gala-Błądzińska, Agnieszka& Dumnicka, Paulina& Kuśnierz-Cabala, Beata& Rybak, Katarzyna& Drozdz, Ryszard& Żyłka, Agnieszka…[et al.]. Urinary Neutrophil Gelatinase-Associated Lipocalin Is Complementary to Albuminuria in Diagnosis of Early-Stage Diabetic Kidney Disease in Type 2 Diabetes. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137310