Surveillance Program for Diagnosis of HCC in Liver Cirrhosis: Role of Ultrasound Echo Patterns
Joint Authors
Soresi, Maurizio
Giannitrapani, Lydia
Montalto, Giuseppe
Terranova, Antonino
Licata, Anna
Brancatelli, Giuseppe
Serruto, Antonietta
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
International guidelines suggest ultrasound surveillance for hepatocellular carcinoma (HCC) early diagnosis in liver cirrhosis (LC) patients, but 40% of nodules <2 cm escape detection.
We investigated the existence of an ultrasound pattern indicating a higher risk of developing HCC in patients under surveillance.
359 patients with LC (Child-Pugh A-B8) underwent ultrasound screening (median follow-up 54 months, range 12–90 months), liver function tests, alpha-fetoprotein assay, and portal hypertension evaluation.
Echo patterns were homogeneous, bright liver, coarse, coarse small nodular pattern, and coarse large nodular pattern.
During follow-up 13.9% developed HCC.
At multivariate analysis using Cox’s model alpha-fetoprotein, coarse large nodular pattern, portal hypertension, and age were independent predictors of HCC development.
Kaplan-Meier estimates of HCC cumulative risk in relation to the baseline echo patterns showed risk of 75% in coarse large nodular pattern patients, 23% coarse small nodular pattern, 21% coarse pattern, 0% homogeneous, and bright liver echo patterns (log-rank test = 23.6, P<0.001).
Coarse large nodular pattern indicates a major risk factor for HCC as 40.7% of patients with this pattern developed HCC.
Homogeneous and bright liver echo patterns and the absence of portal hypertension were not related to HCC.
This observation could raise the question of possibly modifying the follow-up timing in this subset of patients.
American Psychological Association (APA)
Soresi, Maurizio& Terranova, Antonino& Licata, Anna& Serruto, Antonietta& Montalto, Giuseppe& Brancatelli, Giuseppe…[et al.]. 2017. Surveillance Program for Diagnosis of HCC in Liver Cirrhosis: Role of Ultrasound Echo Patterns. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137351
Modern Language Association (MLA)
Soresi, Maurizio…[et al.]. Surveillance Program for Diagnosis of HCC in Liver Cirrhosis: Role of Ultrasound Echo Patterns. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137351
American Medical Association (AMA)
Soresi, Maurizio& Terranova, Antonino& Licata, Anna& Serruto, Antonietta& Montalto, Giuseppe& Brancatelli, Giuseppe…[et al.]. Surveillance Program for Diagnosis of HCC in Liver Cirrhosis: Role of Ultrasound Echo Patterns. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137351