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NLRP1 Overexpression Is Correlated with the Tumorigenesis and Proliferation of Human Breast Tumor
Joint Authors
Wei, Yuxian
Huang, Hongyan
Qiu, Zhu
Li, Hongzhong
Tan, Jinxiang
Ren, Guosheng
Wang, Xiaoyi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Recent studies suggest that nucleotide-binding domain leucine-rich repeat protein 1 (NLRP1) is a pivotal factor in the inflammatory process.
However, the role of NLRP1 in breast cancer pathogenesis remains unclear.
The aim of this study was to examine the expression and function of NLRP1 in breast cancer.
We found that NLRP1 was widely expressed in 83% (60/72) of primary breast cancer tissue.
NLRP1 expression level was higher in primary breast cancer tissue than in adjacent noncancerous tissue (p<0.001) and NLRP1 expression was associated with lymph node metastasis (p=0.003), TNM stage (p=0.003), and Ki-67 levels (p<0.001).
Overexpression of NLRP1 in the breast cancer cell line MCF-7 promotes proliferation, migration, invasion, and tumorigenicity in nude mice.
Restoration of NLRP1 expression resulted in the EMT occurrence that downregulation of epithelial marker E-cadherin and upregulation mesenchymal marker vimentin, C-myc, MMP-9, and snail.
In summary, NLRP1 promotes cell line MCF-7 the proliferation, migration, and invasion through inducing EMT.
American Psychological Association (APA)
Wei, Yuxian& Huang, Hongyan& Qiu, Zhu& Li, Hongzhong& Tan, Jinxiang& Ren, Guosheng…[et al.]. 2017. NLRP1 Overexpression Is Correlated with the Tumorigenesis and Proliferation of Human Breast Tumor. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137360
Modern Language Association (MLA)
Wei, Yuxian…[et al.]. NLRP1 Overexpression Is Correlated with the Tumorigenesis and Proliferation of Human Breast Tumor. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1137360
American Medical Association (AMA)
Wei, Yuxian& Huang, Hongyan& Qiu, Zhu& Li, Hongzhong& Tan, Jinxiang& Ren, Guosheng…[et al.]. NLRP1 Overexpression Is Correlated with the Tumorigenesis and Proliferation of Human Breast Tumor. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137360