Advanced Oxidation Protein Products and Carbonylated Proteins as Biomarkers of Oxidative Stress in Selected Atherosclerosis-Mediated Diseases
Joint Authors
Strzyżewski, Krzysztof Wojciech
Kasprzak, Magdalena
Gryszczyńska, Bogna
Budzyń, Magdalena
Formanowicz, Dorota
Formanowicz, Piotr
Iskra, Maria
Majewski, Wacław
Wanic-Kossowska, Maria
Pawliczak, Elżbieta
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
The main question of this study was to evaluate the intensity of oxidative protein modification shown as advanced oxidation protein products (AOPP) and carbonylated proteins, expressed as protein carbonyl content (C=O) in abdominal aortic aneurysms (AAA), aortoiliac occlusive disease (AIOD), and chronic kidney disease (CKD).
Design and Methods.
The study was carried out in a group of 35 AAA patients and 13 AIOD patients.
However, CKD patients were divided into two groups: predialysis (PRE) included 50 patients or hemodialysis (HD) consisted of 34 patients.
AOPP and C=O were measured using colorimetric assay kit, while C-reactive protein concentration was measured by high-sensitivity assay (hsCRP).
Results.
The concentration of AOPP in both AAA and AIOD groups was higher than in PRE and HD groups according to descending order: AAA~AIOD > HD > PRE.
The content of C=O was higher in the PRE group in comparison to AIOD and AAA according to the descending order: PRE~HD > AAA~AIOD.
Conclusions.
AAA, AIOD, and CKD-related atherosclerosis (PRE and HD) contribute to the changes in the formation of AOPP and C=O.
They may promote modification of proteins in a different way, probably due to the various factors that influence oxidative stress here.
American Psychological Association (APA)
Gryszczyńska, Bogna& Formanowicz, Dorota& Budzyń, Magdalena& Wanic-Kossowska, Maria& Pawliczak, Elżbieta& Formanowicz, Piotr…[et al.]. 2017. Advanced Oxidation Protein Products and Carbonylated Proteins as Biomarkers of Oxidative Stress in Selected Atherosclerosis-Mediated Diseases. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137380
Modern Language Association (MLA)
Gryszczyńska, Bogna…[et al.]. Advanced Oxidation Protein Products and Carbonylated Proteins as Biomarkers of Oxidative Stress in Selected Atherosclerosis-Mediated Diseases. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1137380
American Medical Association (AMA)
Gryszczyńska, Bogna& Formanowicz, Dorota& Budzyń, Magdalena& Wanic-Kossowska, Maria& Pawliczak, Elżbieta& Formanowicz, Piotr…[et al.]. Advanced Oxidation Protein Products and Carbonylated Proteins as Biomarkers of Oxidative Stress in Selected Atherosclerosis-Mediated Diseases. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137380