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The Alleviative Effect of Vitamin B2 on Potassium Bromate-Induced Hepatotoxicity in Male Rats
Joint Authors
Hassan, Iftekhar
Alhazza, Ibrahim
Ebaid, Hossam
Al-Tamimi, Jameel
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Potassium bromate (PB) is a food enhancer, water disinfection by-product, and a proven carcinogen.
It elicits toxicities in the living organism due to exposure and in a dose-dependent manner.
The present study discourses the ameliorative efficacy of riboflavin (RF) in PB-administered rodents.
The animals were distributed into five treatment groups: control (group I), PB alone (group II, 150 mg/kg), RF alone (group III, 2 mg/kg), PB+RF1 (group IV, 150 mg/kg+2 mg/kg), and PB+RF2 (group V, 150 mg/kg+4 mg/kg).
After the round of the treatment, the animals were sacrificed to collect their blood and liver samples for the detailed analysis.
Group II depicted perturbed liver functions evidenced by altered serum and toxicity markers along with the disturbed redox balance.
Also, these biochemical results were found harmonious with histopathological analysis and comet assay.
However, group III showed no noticeable alteration in the same parameters, whereas the combination groups (IV and V) exhibited dose-dependent amelioration in the PB-induced toxicities.
Interestingly, RF favored apoptosis concomitant with suppressing the necrosis in the PB-challenged groups, as shown by the activity of caspase-3 and lactate dehydrogenase.
Histopathological analysis and comet assay further consolidate these results.
Hence, RF has significant alleviative property against PB-induced hepatotoxicity in vivo that can be used in the consumer items containing the toxicant.
American Psychological Association (APA)
Hassan, Iftekhar& Ebaid, Hossam& Alhazza, Ibrahim& Al-Tamimi, Jameel. 2020. The Alleviative Effect of Vitamin B2 on Potassium Bromate-Induced Hepatotoxicity in Male Rats. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137383
Modern Language Association (MLA)
Hassan, Iftekhar…[et al.]. The Alleviative Effect of Vitamin B2 on Potassium Bromate-Induced Hepatotoxicity in Male Rats. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1137383
American Medical Association (AMA)
Hassan, Iftekhar& Ebaid, Hossam& Alhazza, Ibrahim& Al-Tamimi, Jameel. The Alleviative Effect of Vitamin B2 on Potassium Bromate-Induced Hepatotoxicity in Male Rats. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137383