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CD147 as a Novel Prognostic Biomarker for Hepatocellular Carcinoma: A Meta-Analysis
Joint Authors
Peng, Fei
Li, Hui
You, Qian
Li, Hongru
Wu, Dongwen
Jiang, Chunxiang
Deng, Guangtong
Li, Yan
Li, Yuyan
Wu, Yi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We conducted a meta-analysis to investigate the controversial association of CD147 expression with HCC prognosis and clinicopathological characteristics.
Eight studies from PubMed (1966–2016), EMBASE (1980–2016), Cochrane Library (1996–2016), Web of Science (1945–2016), China National Knowledge Infrastructure (1982–2016), and Wanfang databases (1988–2016) were considered.
The associations between CD147 expression and clinicopathological parameters and overall survival (OS) or DFS/RFS were reassessed using the meta-analysis for odds ratio (OR) or hazard ratio (HR) and 95% confidence interval (CI).
CD147 expression was associated with DFS/RFS (HR = 3.26; 95% CI: 1.82–5.83; P<0.0001) but not with OS (HR = 1.35; 95% CI: 0.56–3.29; P=0.51).
We also delved deeper into the association between median survival time and CD147 expression owing to significant heterogeneity and found significant differences between high and low CD147 expression groups with respect to median survival time.
CD147 expression was closely associated with the TNM stage (OR = 0.18; 95% CI: 0.04–0.85; P=0.03) and venous invasion (OR = 6.29; 95% CI: 1.70–23.20; P=0.006).
In contrast, there was no association between CD147 expression and tumor stage, cirrhosis, differentiation, lymph node metastasis, HBsAg, and serum AFP levels.
Thus, CD147 expression is potentially closely related to HCC survival and associated clinicopathological parameters, paving the way for further research.
American Psychological Association (APA)
Peng, Fei& Li, Hui& You, Qian& Li, Hongru& Wu, Dongwen& Jiang, Chunxiang…[et al.]. 2017. CD147 as a Novel Prognostic Biomarker for Hepatocellular Carcinoma: A Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1137384
Modern Language Association (MLA)
Peng, Fei…[et al.]. CD147 as a Novel Prognostic Biomarker for Hepatocellular Carcinoma: A Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1137384
American Medical Association (AMA)
Peng, Fei& Li, Hui& You, Qian& Li, Hongru& Wu, Dongwen& Jiang, Chunxiang…[et al.]. CD147 as a Novel Prognostic Biomarker for Hepatocellular Carcinoma: A Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1137384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137384