Significance of LL-37 on Immunomodulation and Disease Outcome
Joint Authors
Wei, Ming Q.
Ni, Guoying
Liu, Xiaosong
Yang, Binbin
Mosaiab, Tamim
Liu, Wei
Kaur, Jasmine
Jessop, Calvin
Yang, Lu
Fadhil, Rushdi
Yi, Zhengjun
Good, David
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-16
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
LL-37, also called cathelicidin, is an important part of the human immune system, which can resist various pathogens.
A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial activity.
Recently, there have been increasing interest in its immune function.
It was found that LL-37 can have two distinct functions in different tissues and different microenvironments.
Thus, it is necessary to investigate LL-37 immune functions from the two sides of the same coin.
On the one side, LL-37 promotes inflammation and immune response and exerts its anti-infective and antitumor effects; on the other side, it has the ability to inhibit inflammation and promote carcinogenesis.
This review presents a brief summary of its expression, structure, and immunomodulatory effects as well as brief discussions on the role of this small peptide as a key factor in the development and treatment of various inflammation-related diseases and cancers.
American Psychological Association (APA)
Yang, Binbin& Good, David& Mosaiab, Tamim& Liu, Wei& Ni, Guoying& Kaur, Jasmine…[et al.]. 2020. Significance of LL-37 on Immunomodulation and Disease Outcome. BioMed Research International،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1137411
Modern Language Association (MLA)
Yang, Binbin…[et al.]. Significance of LL-37 on Immunomodulation and Disease Outcome. BioMed Research International No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1137411
American Medical Association (AMA)
Yang, Binbin& Good, David& Mosaiab, Tamim& Liu, Wei& Ni, Guoying& Kaur, Jasmine…[et al.]. Significance of LL-37 on Immunomodulation and Disease Outcome. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1137411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137411