CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR-218
Joint Authors
Lin, Erhu
Liu, Shuai
Xiang, Wei
Zhang, Hongbo
Xie, Chaofan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Circular RNAs (circRNAs) play a key role in regulating the tumorigenesis and development of human cancers, including osteosarcoma (OS).
Of note, the molecular mechanism underlying the progression of OS has remained largely unclear.
The present study identified that a novel circRNA circEIF4G2 was upregulated in OS tissues and cells.
Moreover, we constructed a circEIF4G2-mediated ceRNA network and revealed that circEIF4G2 was involved in regulating multiple cancer pathways, such as the EGFR signaling pathway, the PI3K-Akt signaling pathway, and the ErbB signaling pathway.
Loss-of-function assays showed that circEIF4G2 knockdown significantly suppressed OS cell proliferation, migration, and invasion.
Mechanically, we found that circEIF4G2 could directly bind to miR-218, and miR-218 mediated the effect of circEIF4G2 knockdown on OS progression.
In conclusion, the present study showed that circEIF4G2 could be a potential biomarker for OS.
American Psychological Association (APA)
Lin, Erhu& Liu, Shuai& Xiang, Wei& Zhang, Hongbo& Xie, Chaofan. 2020. CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR-218. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137433
Modern Language Association (MLA)
Lin, Erhu…[et al.]. CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR-218. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1137433
American Medical Association (AMA)
Lin, Erhu& Liu, Shuai& Xiang, Wei& Zhang, Hongbo& Xie, Chaofan. CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR-218. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137433