![](/images/graphics-bg.png)
The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction
Joint Authors
Oliveira, Paula
Peixoto, Francisco P.
Nogueira, António
Oliveira, Maria Manuel
Pires, Carlos André
Colaço, Bruno
Pires, Maria João
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in a model of renal mass reduction.
Methods.
Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO).
One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment (n=14); RMR + CAA: RMR rats treated with CAA (n=13); SO: SO rats without treatment (n=13); and SO + CAA: SO rats treated with CAA (n=13).
CAA was intraperitoneally administered in a dose of 0.23 µg/Kg three times a week for six months.
Results.
RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity (p<0.05) and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio.
CAA administration significantly increased catalase and GR activity (p<0.05) and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio.
No significant differences were found between the RMR groups in any of the parameters of renal function.
However, CAA administration slightly improves some parameters of renal function.
Conclusions.
These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress.
American Psychological Association (APA)
Nogueira, António& Oliveira, Maria Manuel& Pires, Carlos André& Colaço, Bruno& Oliveira, Paula& Pires, Maria João…[et al.]. 2017. The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137434
Modern Language Association (MLA)
Oliveira, Maria Manuel…[et al.]. The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1137434
American Medical Association (AMA)
Nogueira, António& Oliveira, Maria Manuel& Pires, Carlos André& Colaço, Bruno& Oliveira, Paula& Pires, Maria João…[et al.]. The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137434