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In Vitro Screening of Three Indian Medicinal Plants for Their Phytochemicals, Anticholinesterase, Antiglucosidase, Antioxidant, and Neuroprotective Effects
Joint Authors
Penumala, Mohan
Zinka, Raveendra Babu
Shaik, Jeelan Basha
Amooru Gangaiah, Damu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cooccurrence of Diabetes Mellitus and Alzheimer’s disease in elder people prompts scientists to develop multitarget agents that combat causes and symptoms of both diseases simultaneously.
In line with this modern paradigm and as a follow-up to our previous studies, the present study is designed to investigate the crude methanolic extracts and subsequent CHCl3, n-BuOH, and H2O fractions of Acalypha alnifolia, Pavetta indica, and Ochna obtusata for their inhibitory activities towards specific targets involved in AD and DM, namely, acetylcholinesterase, butyrylcholinesterase, and α-glucosidase (α-Glc).
The methanolic extract and its derived chloroform fractions exhibited remarkable inhibitory capacities with IC50 values being found at the μg/mL level.
Further studies on most active chloroform fractions presented a prominent ability to scavenge DPPH and ABTS reactive species and highest neuroprotective effect against H2O2 induced cell injury.
Phytochemical analysis showed a large amount of phenolics, flavonoids, and terpenoids in active fractions.
In conclusion, A.
alnifolia, P.
indica, and O.
obtusata could be promising sources for the treatment of AD and DM since these fractions induced significant anticholinesterase, antidiabetic, antioxidant, and neuroprotection effects attributable to phenolic, flavonoid, and terpenoid contents and encourage further studies for development of multifunctional therapeutic agent for AD and DM dual therapy.
American Psychological Association (APA)
Penumala, Mohan& Zinka, Raveendra Babu& Shaik, Jeelan Basha& Amooru Gangaiah, Damu. 2017. In Vitro Screening of Three Indian Medicinal Plants for Their Phytochemicals, Anticholinesterase, Antiglucosidase, Antioxidant, and Neuroprotective Effects. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1137449
Modern Language Association (MLA)
Penumala, Mohan…[et al.]. In Vitro Screening of Three Indian Medicinal Plants for Their Phytochemicals, Anticholinesterase, Antiglucosidase, Antioxidant, and Neuroprotective Effects. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1137449
American Medical Association (AMA)
Penumala, Mohan& Zinka, Raveendra Babu& Shaik, Jeelan Basha& Amooru Gangaiah, Damu. In Vitro Screening of Three Indian Medicinal Plants for Their Phytochemicals, Anticholinesterase, Antiglucosidase, Antioxidant, and Neuroprotective Effects. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1137449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137449