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Role of Vascular Endothelial Cells in Disseminated Intravascular Coagulation Induced by Seawater Immersion in a Rat Trauma Model
Joint Authors
Zhang, Da-Jin
Qu, Jia
Xiong, Ming
Qiao, Yuanyuan
Wang, Dapeng
Liu, Fengjiao
Li, Dandan
Hu, Ming
Zhang, Jiashu
Wang, Fuyu
Zhao, Xiaohang
Shi, Chenghe
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Trauma complicated by seawater immersion is a complex pathophysiological process with higher mortality than trauma occurring on land.
This study investigated the role of vascular endothelial cells (VECs) in trauma development in a seawater environment.
An open abdominal injury rat model was used.
The rat core temperatures in the seawater (SW, 22°C) group and normal sodium (NS, 22°C) group declined equivalently.
No rats died within 12 hours in the control and NS groups.
However, the median lethal time of the rats in the SW group was only 260 minutes.
Among the 84 genes involved in rat VEC biology, the genes exhibiting the high expression changes (84.62%, 11/13) on a qPCR array were associated with thrombin activity.
The plasma activated partial thromboplastin time and fibrinogen and vWF levels decreased, whereas the prothrombin time and TFPI levels increased, indicating intrinsic and extrinsic coagulation pathway activation and inhibition, respectively.
The plasma plasminogen, FDP, and D-dimer levels were elevated after 2 hours, and those of uPA, tPA, and PAI-1 exhibited marked changes, indicating disseminated intravascular coagulation (DIC).
Additionally, multiorgan haemorrhagia was observed.
It indicated that seawater immersion during trauma may increase DIC, elevating mortality.
VECs injury might play an essential role in this process.
American Psychological Association (APA)
Zhang, Da-Jin& Qu, Jia& Xiong, Ming& Qiao, Yuanyuan& Wang, Dapeng& Liu, Fengjiao…[et al.]. 2017. Role of Vascular Endothelial Cells in Disseminated Intravascular Coagulation Induced by Seawater Immersion in a Rat Trauma Model. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137455
Modern Language Association (MLA)
Zhang, Da-Jin…[et al.]. Role of Vascular Endothelial Cells in Disseminated Intravascular Coagulation Induced by Seawater Immersion in a Rat Trauma Model. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1137455
American Medical Association (AMA)
Zhang, Da-Jin& Qu, Jia& Xiong, Ming& Qiao, Yuanyuan& Wang, Dapeng& Liu, Fengjiao…[et al.]. Role of Vascular Endothelial Cells in Disseminated Intravascular Coagulation Induced by Seawater Immersion in a Rat Trauma Model. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137455