An Immune-Related Gene Panel for Preoperative Lymph Node Status Evaluation in Advanced Gastric Cancer
Joint Authors
Yang, Yuan
Zheng, Ya
Zhang, Hongling
Miao, Yandong
Wu, Guozhi
Zhou, Lingshan
Wang, Haoying
Ji, Rui
Guo, Qinghong
Chen, Zhaofeng
Wang, Jiangtao
Wang, Yuping
Zhou, Yongning
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aim: Gastric cancer (GC) is the common leading cause of cancer-related death worldwide.
Immune-related genes (IRGs) may potentially predict lymph node metastasis (LNM).
We aimed to develop a preoperative model to predict LNM based on these IRGs.
Methods: In this paper, we compared and evaluated three machine learning models to predict LNM based on publicly available gene expression data from TCGA-STAD.
The Pearson correlation coefficient (PCC) method was utilized to feature selection according to its relationships with LN status.
The performance of the model was assessed using the area under the curve (AUC) and F1 score.
Results: The Naive Bayesian model showed better performance and was constructed based on 26 selected gene features, with AUCs of 0.741 in the training set and 0.688 in the test set.
The F1 score in the training set and test set was 0.652 and 0.597, respectively.
Furthermore, Naive Bayesian model based on 26 IRGs is the first diagnostic tool for the identification of LNM in advanced GC.
Conclusion: These results indicate that our new methods have the value of auxiliary diagnosis with promising clinical potential.
American Psychological Association (APA)
Yang, Yuan& Zheng, Ya& Zhang, Hongling& Miao, Yandong& Wu, Guozhi& Zhou, Lingshan…[et al.]. 2020. An Immune-Related Gene Panel for Preoperative Lymph Node Status Evaluation in Advanced Gastric Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1137465
Modern Language Association (MLA)
Yang, Yuan…[et al.]. An Immune-Related Gene Panel for Preoperative Lymph Node Status Evaluation in Advanced Gastric Cancer. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1137465
American Medical Association (AMA)
Yang, Yuan& Zheng, Ya& Zhang, Hongling& Miao, Yandong& Wu, Guozhi& Zhou, Lingshan…[et al.]. An Immune-Related Gene Panel for Preoperative Lymph Node Status Evaluation in Advanced Gastric Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1137465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137465