Tranexamic Acid for Blood Loss after Transforaminal Posterior Lumbar Interbody Fusion Surgery: A Double-Blind, Placebo-Controlled, Randomized Study
Joint Authors
He, Bin
Li, Yuanqiang
Xu, Shuai
Ou, Yunsheng
Zhao, Jinqiu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Transforaminal lumbar interbody fusion (TLIF) may result in significant blood loss and an increase in blood transfusion.
Though tranexamic acid (TXA) is widely studied for the hemostasis of arthroplasty, there is little information on the use of TXA for TLIF surgery.
Methods.
This prospective randomized, double-blind, placebo-controlled trial was conducted to study the influence of TXA (intravenous bolus of 10 mg/kg 15 minutes before skin incision followed by intravenous infusion of 6-8 mg/kg/h up to a total dose of 15 mg/kg during the surgery) on the blood loss and Enhanced Recovery After Surgery (ERAS) after TLIF surgery.
40 patients were randomized into two groups: TXA group (tranexamic acid) and control group (placebo).
Baseline characteristics were comparable between the TXA group and the control group before the surgery.
Outcomes assessed included blood loss, total postoperative drainage, time for drainage removal, time to ambulation, hospital stay after surgery, postoperative hemoglobin (Hb) one day after surgery, and adverse events.
Results.
Compared to patients in the control group after TLIF surgery, patients in the TXA group have significantly reduced intraoperative hemorrhage and time to ambulation after surgery but show similar hospital stay, postoperative drainage, time for drainage removal, postoperative Hb one day after surgery, and adverse events.
Conclusions.
TXA shows important ability in controlling blood loss and promoting the ERAS after TLIF surgery.
American Psychological Association (APA)
He, Bin& Li, Yuanqiang& Xu, Shuai& Ou, Yunsheng& Zhao, Jinqiu. 2020. Tranexamic Acid for Blood Loss after Transforaminal Posterior Lumbar Interbody Fusion Surgery: A Double-Blind, Placebo-Controlled, Randomized Study. BioMed Research International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1137497
Modern Language Association (MLA)
He, Bin…[et al.]. Tranexamic Acid for Blood Loss after Transforaminal Posterior Lumbar Interbody Fusion Surgery: A Double-Blind, Placebo-Controlled, Randomized Study. BioMed Research International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1137497
American Medical Association (AMA)
He, Bin& Li, Yuanqiang& Xu, Shuai& Ou, Yunsheng& Zhao, Jinqiu. Tranexamic Acid for Blood Loss after Transforaminal Posterior Lumbar Interbody Fusion Surgery: A Double-Blind, Placebo-Controlled, Randomized Study. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1137497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137497