Deviation of the Fecal Stream in Colonic Bowel Segments Results in Increased Numbers of Isolated Lymphoid Follicles in the Submucosal Compartment in a Novel Murine Model of Diversion Colitis
Joint Authors
Heidecke, Claus-Dieter
Kleinwort, Annabel
Döring, Paula
Hackbarth, Christine
Schulze, Tobias
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
Diversion colitis is a significant health problem due to its high incidence in patients with diverting enterostomy.
This mucosal inflammation presents characteristic histopathological features allowing for the differentiation of this entity from other inflammatory bowel diseases.
The pathophysiology of this disease remains ill-defined, in part due to the lack of appropriate animal models.
The present study was performed in order to develop and characterize a murine model of diversion colitis.
Methods.
A diverting loop colostomy was performed in C57BL/6 mice either in the ascending colon or in the transverse colon.
Animals were assessed for clinical and histopathological parameters during short-term and long-term survival.
Results.
Animals with a colostomy in the transverse colon showed a good long-term survival and developed a mild colitis in the bypassed bowel closely resembling the human pathology on a histopathological level.
Conclusion.
This model is a promising tool to further elucidate the pathomechanism leading to impaired mucosal homeostasis in bypassed colonic segments.
Moreover, the establishment of the model in the C57BL/6 background allows the combination of this colitis model with various transgenic mouse strains to investigate the effect of locally deregulated mucosal immunity on systemic immune homeostasis and to develop specific therapeutic strategies.
American Psychological Association (APA)
Kleinwort, Annabel& Döring, Paula& Hackbarth, Christine& Heidecke, Claus-Dieter& Schulze, Tobias. 2017. Deviation of the Fecal Stream in Colonic Bowel Segments Results in Increased Numbers of Isolated Lymphoid Follicles in the Submucosal Compartment in a Novel Murine Model of Diversion Colitis. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137514
Modern Language Association (MLA)
Kleinwort, Annabel…[et al.]. Deviation of the Fecal Stream in Colonic Bowel Segments Results in Increased Numbers of Isolated Lymphoid Follicles in the Submucosal Compartment in a Novel Murine Model of Diversion Colitis. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1137514
American Medical Association (AMA)
Kleinwort, Annabel& Döring, Paula& Hackbarth, Christine& Heidecke, Claus-Dieter& Schulze, Tobias. Deviation of the Fecal Stream in Colonic Bowel Segments Results in Increased Numbers of Isolated Lymphoid Follicles in the Submucosal Compartment in a Novel Murine Model of Diversion Colitis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137514