The Association of Serum Levels of Brain-Derived Neurotrophic Factor with the Occurrence of and Recovery from Delirium in Older Medical Inpatients
Joint Authors
Adamis, Dimitrios
Meagher, David J.
Williams, John
Finn, Karen
Melvin, Vincent
McCarthy, Geraldine
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Limited studies of the association between BDNF levels and delirium have given inconclusive results.
This prospective, longitudinal study examined the relationship between BDNF levels and the occurrence of and recovery from delirium.
Participants were assessed twice weekly using MoCA, DRS-R98, and APACHE II scales.
BDNF levels were estimated using an ELISA method.
Delirium was defined with DRS-R98 (score > 16) and recovery from delirium as ≥2 consecutive assessments without delirium prior to discharge.
We identified no difference in BDNF levels between those with and without delirium.
Excluding those who never developed delirium (n=140), we examined the association of BDNF levels and other variables with delirium recovery.
Of 58 who experienced delirium, 39 remained delirious while 19 recovered.
Using Generalized Estimating Equations models we found that BDNF levels (Wald χ2=7.155; df: 1, p=0.007) and MoCA (Wald χ2=4.933; df: 1, p=0.026) were associated with recovery.
No significant association was found for APACHE II, dementia, age, or gender.
BDNF levels do not appear to be directly linked to the occurrence of delirium but recovery was less likely in those with continuously lower levels.
No previous study has investigated the role of BDNF in delirium recovery and these findings warrant replication in other populations.
American Psychological Association (APA)
Williams, John& Finn, Karen& Melvin, Vincent& Meagher, David J.& McCarthy, Geraldine& Adamis, Dimitrios. 2017. The Association of Serum Levels of Brain-Derived Neurotrophic Factor with the Occurrence of and Recovery from Delirium in Older Medical Inpatients. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137522
Modern Language Association (MLA)
Williams, John…[et al.]. The Association of Serum Levels of Brain-Derived Neurotrophic Factor with the Occurrence of and Recovery from Delirium in Older Medical Inpatients. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1137522
American Medical Association (AMA)
Williams, John& Finn, Karen& Melvin, Vincent& Meagher, David J.& McCarthy, Geraldine& Adamis, Dimitrios. The Association of Serum Levels of Brain-Derived Neurotrophic Factor with the Occurrence of and Recovery from Delirium in Older Medical Inpatients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137522