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p21-Activated Kinase 4 Promotes Intimal Hyperplasia and Vascular Smooth Muscle Cells Proliferation during Superficial Femoral Artery Restenosis after Angioplasty
Joint Authors
Yuan, Liangxi
Duan, Xianli
Dong, Jian
Lu, Qingsheng
Zhou, Jian
Zhao, Zhiqing
Bao, Junmin
Jing, Zaiping
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study is to explore the function of p21-activated kinase 4 (PAK4) in intimal hyperplasia (IH) and vascular smooth muscle cells (VSMCs) proliferation.
We choose vascular samples from patients undergoing angioplasty in superficial femoral artery (SFA) as the experimental group and vascular samples from donors without clinical SFA restenosis as the control group, respectively.
We draw from the results that both levels of mRNA and protein of PAK4 in the experimental group increased dramatically compared with the control group.
IH arose from angioplasty of SFA.
Moreover, overexpression of PAK4 dramatically contributed to cell proliferation of VSMCs and promoted cell cycle progression from G0/G1 phase (71.12±0.69% versus 58.77±0.77%, P<0.001) into S phase (23.99±0.21% versus 31.35±0.33%, P<0.001).
Besides, PAK4 downregulated the level of p21 and enhanced the activity of Akt as well.
And we conclude that PAK4 acts as a regulator of cell cycle progression of VSMC by mediating Akt signaling and controlling p21 levels, which further modulate IH and VSMCs’ proliferation.
American Psychological Association (APA)
Yuan, Liangxi& Duan, Xianli& Dong, Jian& Lu, Qingsheng& Zhou, Jian& Zhao, Zhiqing…[et al.]. 2017. p21-Activated Kinase 4 Promotes Intimal Hyperplasia and Vascular Smooth Muscle Cells Proliferation during Superficial Femoral Artery Restenosis after Angioplasty. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137542
Modern Language Association (MLA)
Yuan, Liangxi…[et al.]. p21-Activated Kinase 4 Promotes Intimal Hyperplasia and Vascular Smooth Muscle Cells Proliferation during Superficial Femoral Artery Restenosis after Angioplasty. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137542
American Medical Association (AMA)
Yuan, Liangxi& Duan, Xianli& Dong, Jian& Lu, Qingsheng& Zhou, Jian& Zhao, Zhiqing…[et al.]. p21-Activated Kinase 4 Promotes Intimal Hyperplasia and Vascular Smooth Muscle Cells Proliferation during Superficial Femoral Artery Restenosis after Angioplasty. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137542