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HMGN5 Silencing Suppresses Cell Biological Progression via AKTMAPK Pathway in Human Glioblastoma Cells
Joint Authors
Song, Wen
Ma, Quanfeng
Wang, Xiuyu
Wang, Hong
Wang, Qiong
Wang, Jinhuan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
HMGN5 regulates biological function and molecular transcription via combining with a nucleosome.
There has been growing evidence that aberrant expression of HMGN5 is associated with malignant neoplasm development and progression.
In the present study, we found that the expression of HMGN5 is significantly higher in high-grade glioblastoma tissues than in low-grade samples.
To clarify the function of HMGN5 in glioblastoma, we knocked down HMGN5 in U87 and U251 glioblastoma cells via siRNA.
The results demonstrated that HMGN5 was involved in the regulation of proliferation and apoptosis, migration, and invasion of glioblastoma cells.
These outcomes also indicated that silencing HMGN5 possibly suppressed the expression of p-AKT and p-ERK1/2.
Taken together, our research reveals that HMGN5 might be an efficient target for glioblastoma-targeted therapy.
American Psychological Association (APA)
Ma, Quanfeng& Wang, Xiuyu& Wang, Hong& Song, Wen& Wang, Qiong& Wang, Jinhuan. 2020. HMGN5 Silencing Suppresses Cell Biological Progression via AKTMAPK Pathway in Human Glioblastoma Cells. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1137562
Modern Language Association (MLA)
Ma, Quanfeng…[et al.]. HMGN5 Silencing Suppresses Cell Biological Progression via AKTMAPK Pathway in Human Glioblastoma Cells. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1137562
American Medical Association (AMA)
Ma, Quanfeng& Wang, Xiuyu& Wang, Hong& Song, Wen& Wang, Qiong& Wang, Jinhuan. HMGN5 Silencing Suppresses Cell Biological Progression via AKTMAPK Pathway in Human Glioblastoma Cells. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1137562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137562